Systemic therapy

Drug therapy to achieve the recommended target blood pressure remains the cornerstone of the management of hypertension. Today, there are strong evidences from randomized controlled trials that antihypertensive drugs are more effective than placebo at reducing cardiovascular mortality and morbidity.

8p vifaye 20-09-2024 3 1   Download

Bacterial infections have a substantial impact on global health and can become serious if misdiagnosed with several diseases related to the central nervous, cardiovascular, and respiratory systems. The prognosis in patients with infectious disease strongly depends on early diagnosis and appropriate antibiotic therapy.

8p vifaye 20-09-2024 3 1   Download

Acute respiratory distress syndrome (ARDS) in premature infants is one of the leading causes of death. Surfactant replacement therapy has been the mainstay of treatment for preterm infants with RDS. This study aimed to evaluate the results of surfactant therapy for premature infants with RDS at the Pediatric Center of Hue Central Hospital.

6p vinatisu 29-08-2024 0 0   Download

This study presents the development of a software support system aimed at improving targeted treatment outcomes in non-small cell lung cancer (NSCLC) by utilizing genetic mutation analysis data. PubMed BERT model were generated to identify tumor gene mutated features associated with gene-drug responses.

14p vinatisu 23-08-2024 4 1   Download

The primary aims of this thesis are: A) to measure the dependence of the DAPR20,10 on the size of the primary small photon field, and to relate this data to TPR20,10 of the reference field. B) to develop a method of using a large-area ionization chamber to compare the measured dosearea product to that calculated by a treatment planning system. C) To gain further understanding of the dose-area product by supplementing the results with 2D high resolution film dosimetry.

149p runthenight04 02-02-2023 8 3   Download

Colorectal cancer (CRC) is still one of the most common types of cancer in the world, and the gut microbiome plays an important role in its development. The microbiome is involved in the carcinogenesis, formation and progression of CRC as well as its response to different systemic therapies.

13p vielonmusk 21-01-2022 11 0   Download

The ESR1 gene encodes Estrogen Receptor alpha (ERα), which plays a role in the tumourigenesis of breast cancer. A single nucleotide polymorphism (SNP) in intron 1 of this gene called ESR1 PvuII (rs2234693) has been reported to increase the risk of breast cancer. This study aimed to investigate the ESR1 PvuII polymorphism as a prognostic and predictive factor guiding the choice of therapy for advanced breast cancer.

7p vielonmusk 21-01-2022 39 1   Download

Nghiên cứu tiếp cận hệ thống (systemic approach) và liệu pháp câu chuyện kể (narrative therapy) cũng được lồng ghép, vận dụng trong tiến trình tham vấn để giúp thân chủ nhận lấy trách nhiệm “sáng tác” câu chuyện chọn trường lựa ngành của mình, hình dung mình ở đâu trong bức tranh chung của bối cảnh gia đình và xã hội quanh mình, từ đó sáng tỏ hơn trong từng lựa chọn của bản thân và can đảm để dấn thân, đeo đuổi những gì mình đã chọn. Mời các bạn tham khảo!

17p mudbound 06-12-2021 18 3   Download

This study with the following objectives: Study some characteristics of immune disorders, analysis of association with target organ damage and activity level (SLEDAI score) in patients with severe systemic lupus erythematosus. Evaluation of treatment outcome of pulsed methylprednisolone therapy combined with baseline treatment after 12 weeks in patients with severe systemic lupus erythematosus.

34p petsematary 02-06-2021 26 4   Download

Mucopolysaccharidosis type I (MPS I) results from a deficiency in the enzyme a-L-iduronidase (IDUA), and is characterized by skeletal abnormalities, hepatosplenomegaly and neurological dysfunction. In this study, we used a late generation lentiviral vector to evaluate the utility of this vector system for the transfer and expression of the human IDUA cDNA in MPS I fibroblasts. We observed that the level of enzyme expression in transduced cells was 1.5-fold the level found in normal cells; the expression persisted for at least two months....

8p system191 01-06-2013 31 5   Download

There are at least three well-defined signalling cascades engaged directly in the physiological regulation of cardiac circulatory function: theb1-adrenoceptors that control the cardiac contractile apparatus,the renin-angiotensin-aldo-sterone system involved in regulating bloodpressure and the natriuretic peptides contributing at least to the factors determining circulating volume.

18p research12 29-04-2013 39 3   Download

Owing to theuseof porphyrins inphotodynamic therapy for the treatment of malignant tumors, and the preferential interaction of lectins with tumor cells, studies on lectin– porphyrin interactionareof significant interest. In this study, the interaction of several free-base and metalloporphyrins withMomordica charantia(bitter gourd) lectin (MCL) was investigated by absorption spectroscopy. Difference absorp-tion spectra revealed that significant changes occur in the Soret band region of the porphyrins on binding to MCL....

0p awards 05-04-2013 53 3   Download

The spontaneous acquisition of resistance to a variety of unrelated cytotoxic compounds has important implications in medical treatment of infectious diseases and anticancer therapy. In the yeast Saccharomyces cerevisiaethis pheno-menon is caused by overexpression of membrane efflux pumps and is called pleiotropic drug resistance. We have found that allelic forms of the genes for the transcription activators Pdr1p and Pdr3p, designated PDR1-12and PDR3-33,respectively, mediate resistance to diazaborine....

8p dell39 03-04-2013 38 3   Download

Regulated gene expression may substantially enhance gene therapy. Corre-lated with structural differences between insect ecdysteroids and mamma-lian steroids, the ecdysteroids appear to have a benign pharmacology without adversely interfering with mammalian signaling systems. Conse-quently, the ecdysone receptor-based gene switches are attractive for appli-cation in medicine.

21p media19 04-03-2013 36 5   Download

Cause-specific survival is commonly estimated in cancer clinical trials and only those deaths which can be attributed to the cancer in question are considered to be events, while all other deaths are considered censorings. Using cause-specific survival to estimate net survival requires that reliably coded information on cause of death is available. The distinguishing feature of survival analysis is that at the end of the follow-up period the event (such as death due to cancer) will probably not have occurred for all patients.

226p wqwqwqwqwq 20-07-2012 83 5   Download

Intermediate-risk patients are those with any of the following criteria: microscopic tumour invasion into the perithyroidal tissues at initial surgery, cervical lymph node metastases or 131I uptake outside the thyroid bed on the initial post-treatment scan, or tumour with aggressive histology or vascular invasion. Finally, high-risk patients have macroscopic tumour invasion, incomplete tumour resection, distant metastases or elevated thyroglobulin out of proportion to what is seen on the post-treatment scan (Cooper et al., 2009).

398p wqwqwqwqwq 20-07-2012 108 5   Download

Accurate statistics on cancer occurrence and outcome are essential both for the purposes of research and for planning and evaluation programmes for cancer control (Parkin, 2006). Although tumours of thyroid account for only 1% of the overall human cancer burden, they represent the most common malignancies of the endocrine system and pose a significant challenge to pathologists, surgeons and endocrinologists. Among epithelial tumors, carcinomas of follicular cell origin far outnumber those of C-cell origin.

444p wqwqwqwqwq 20-07-2012 78 8   Download

Pancreatic cancer is one of the most fatal human malignancies with extremely poor prognosis making it the fourth leading cause of cancer-related deaths in the United States. The molecular mechanisms of pancreatic carcinogenesis are not well understood. The major focus of these two books is towards the understanding of the basic biology of pancreatic carcinogenesis, identification of newer molecular targets and the development of adjuvant and neoadjuvant therapies.

324p wqwqwqwqwq 20-07-2012 136 10   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Research Article Continuous Drug Infusion for Diabetes Therapy: A Closed-Loop Control System Design

10p sting10 24-02-2012 47 7   Download

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa hoc quốc tế đề tài : The application of carbon nanotubes in target drug delivery systems for cancer therapies

22p dauphong11 06-02-2012 74 8   Download