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Therapeutic efficacy
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This study aimed to systematically analyze the effect of a serine/threonine kinase (STK11) mutation (STK11mut) on therapeutic efficacy and prognosis in patients with non-small cell lung cancer (NSCLC).
12p
vishanshan
27-06-2024
2
1
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Breast carcinoma (BC) ranks as a predominant malignancy and constitutes the second principal cause of mortality among women globally. Epirubicin stands as the drug of choice for BC therapeutics. Nevertheless, the emergence of chemoresistance has significantly curtailed its therapeutic efficacy.
13p
vikoch
27-06-2024
3
1
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There are multiple existing and emerging therapeutic avenues for metastatic prostate cancer, with a common denominator, which is the need for predictive biomarkers. Circulating tumor DNA (ctDNA) has the potential to cost-efficiently accelerate precision medicine trials to improve clinical efficacy and diminish costs and toxicity. However, comprehensive ctDNA profiling in metastatic prostate cancer to date has been limited.
13p
vibransone
28-03-2024
3
2
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Cancer patients often show no or only modest benefit from a given therapy. This major problem in oncology is generally attributed to the lack of specific predictive biomarkers, yet a global measure of cancer cell activity may support a comprehensive mechanistic understanding of therapy efficacy. We reasoned that network analysis of omic data could help to achieve this goal.
12p
vioraclene
31-03-2024
3
1
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The circadian clock and the daily rhythms it produces are crucial for human health, but are often disrupted by the modern environment. At the same time, circadian rhythms may influence the efficacy and toxicity of therapeutics and the metabolic response to food intake.
11p
vioraclene
31-03-2024
6
1
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Ebook Future trends in biotechnology (Advances in Biochemical engineering/biotechnology, Volume 131)
Ebook "Future trends in biotechnology (Advances in Biochemical engineering/biotechnology, Volume 131)" provides readers with contents including: systems metabolic engineering - the creation of microbial cell factories by rational metabolic design and evolution; impacts of quorum sensing on microbial metabolism and human health; CHO glycosylation mutants as potential host cells to produce therapeutic proteins with enhanced efficacy;...
175p
coduathanh1122
27-03-2024
2
1
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Part 2 book "Cryptosporidium - Methods and protocols" includes content: Use of mirnas to study host cell–parasite interactions; genetic manipulation of cryptosporidium parvum with crispr cas9; mouse models for use in cryptosporidium infection studies and quantification of parasite burden using flow cytometry, QPCR, and histopathology; calf clinical model of cryptosporidiosis for efficacy evaluation of therapeutics,... and other contents.
201p
muasambanhan05
16-01-2024
1
0
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Recapitulating the tumor microenvironment (TME) in vitro remains a major hurdle in cancer research. In recent years, there have been significant strides in this area, particularly with the emergence of 3D spheroids as a model system for drug screening and therapeutics development for solid tumors. However, incorporating macrophages into these spheroid cultures poses specific challenges due to the intricate interactions between macrophages and cancer cells.
17p
vileonardodavinci
23-12-2023
4
2
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Novel ADC drugs provide a new therapeutic strategy for gastric cancer.The present study aimed to analyze the clinical efficacy and drug toxicities of disitamab vedotin (RC48) plus immune checkpoint inhibitors(ICIs) and RC48 as third-line therapies and beyond for advanced and metastatic gastric cancer patients.
8p
vileonardodavinci
23-12-2023
3
3
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Little is known on the relationship between the expression of pyroptosis related genes (PRGs) and prognosis of hepatocellular carcinoma (HCC). In this study, a specific PRG prognostic model was developed with an aim to improve therapeutic efficacy among HCC patients.
15p
vialfrednobel
23-12-2023
4
3
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S-1 adjuvant chemotherapy is the standard treatment in Asia for resectable pancreatic ductal adenocarcinoma. The relative dose intensity of adjuvant chemotherapy influences survival in pancreatic cancer but does not precisely reflect treatment schedule modifications. We investigated the effects of total dose intensity of S-1 adjuvant chemotherapy on the survival of patients with pancreatic cancer and the permissible dose reduction.
9p
vialfrednobel
23-12-2023
7
3
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Composition of the intestinal microbiota has been correlated to therapeutic efficacy of immune check‑point inhibitors (ICI) in various cancer entities including melanoma. Prediction of the outcome of such therapy, how‑ever, is still unavailable.
11p
vialfrednobel
23-12-2023
2
2
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The mammalian target of rapamycin (mTOR) kinase, a central component of the PI3K/AKT/mTOR pathway, plays a critical role in tumor biology as an attractive therapeutic target. We conducted this first-in-human study to investigate the safety, pharmacokinetics (PK), and pilot efficacy of LXI-15029, an mTORC1/2 dual inhibitor, in Chinese patients with advanced malignant solid tumors.
12p
vialfrednobel
23-12-2023
2
2
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Part 1 book "Equine-Assisted therapy and learning with at risk young people" includes content: Background to equine assisted therapy and learning; young people considered "at risk", and overview of "the yard" and methods used; development of self confidence and self efficacy, and the opening up of "positive experiences" and "positive opportunities" through therapeutic horsemanship.
119p
oursky10
04-12-2023
7
3
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Programmed Cell Death-1/ Programmed Death-ligand 1 (PD-1 / PD-L1) inhibitor therapies targeting immunocytes induce persistent tumor remission in various cancers. However, the appropriate biomarkers for the therapeutic efficacy of PD-L1 and PD-1 blockade remain elusive.
13p
vischultz
20-10-2023
3
1
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Overall survival (OS) is the gold standard to assess novel therapeutics to treat cancer. However, to identify early efficacy and speed up drug approval, trials have used progression-free survival (PFS) as a surrogate endpoint (SE). Herein, we aimed to examine if PFS could function as an OS surrogate in advanced Esophageal Squamous Cell Carcinoma (ESCC) treated with first-line immunochemotherapy.
13p
vischultz
20-10-2023
3
1
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Metastatic castration-resistant prostate cancer (mCRPC) remains a therapeutic challenge and evidence for late-line treatments in real-life is limited. The present study investigates the efficacy and safety of an oral metronomic chemo-hormonal regimen including cyclophosphamide, etoposide, estramustine, ketoconazole and prednisolone (KEES) administered in a consecutive biweekly schedule.
10p
vischultz
20-10-2023
5
2
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Over the past decade, there has been increasing availability of novel therapeutics with improved tolerability and efficacy for advanced non-small cell lung cancer (NSCLC). The study goals were: to compare the uptake of systemic therapy (ST) before and after the availability of targeted tyrosine kinase inhibitors (TKI) and immunotherapy and to examine the changes in overall survival (OS) over time between younger and older adults with advanced NSCLC.
11p
vischultz
20-10-2023
2
1
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Part 1 book "Complementary and alternative veterinary medicine considered" includes content: The braid of the alternative medicine movement, historical aspects of some cavm therapies, science and medical therapy; ethics, evidence, and medicine; placebos and perceptions of therapeutic efficacy.
116p
oursky05
23-10-2023
9
3
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The prognosis of patients with advanced biliary tract cancer (BTC) who have progressed on gemcit‑abine plus cisplatin is dismal. Trifluridine/tipiracil (FTD/TPI) and irinotecan have proven efficacy in different gastroin‑ testinal malignancies. We therefore hypothesized that this combination might improve the therapeutic outcome in patients with BTC after failure of first-line treatment.
12p
visharma
20-10-2023
2
2
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