Treatment resistance

Rituximab has been reported to be effective in patients with refractory CIDP, especially those with IgG4 autoantibodies against nodal and paranodal proteins. This study reports the clinical characteristics of three cases diagnosed with refractory CIDP successfully treated with rituximab, although testing for IgG4 antibodies is currently not available in Vietnam.

6p viyamanaka 06-02-2025 2 2   Download

Group B streptococcus (GBS) infections are still the leading cause of invasive infections in neonates, specically they also seriously cause mortality and morbidity with underlying diseases in adults. Curently, there are ten GBS serotypes (Ia, Ib, and II-IX) and the resistance characteristic of GBS is important to clinical treatment.

5p viharuno 03-01-2025 5 2   Download

Drug resistant tuberculosis (DR-TB) remains a global health problem. The diagnosis, treatment, and management of DR-TB are the major challenges to Vietnam National Tuberculosis Control Program. One of the most important solutions for overcoming this problem is developing reliable and low-cost methods, which have been proposed to Drug Susceptibility Testing (DST) to detect drug resistant tuberculosis.

6p viharuno 03-01-2025 16 2   Download

According to statistical data of many countries in the wold, the more proportion of patients in hip replacement have, the more prosthetic infection have been treated. In Vietnam, treatment of prosthetic infection is often difficult beacause of antibiotic resistance, high cost treatment and difficult rehabilitation in post-surgery.

14p viuchiha 03-01-2025 3 2   Download

Bài giảng Chiến lược mới chẩn đoán và xử trí tăng huyết áp kháng trị (new strategy of diagnosis and treatment of resistant hypertension) của BS. Nguyễn Thanh Hiền trình bày về đặc điểm và nguyên nhân; đánh giá bệnh nhân; đề nghị điều trị đối với bệnh nhân tăng huyết áp kháng trị.

71p thuytrang_7 27-08-2015 126 21   Download

Analysis of the rate of resistance to Amoxicillin, Clarithromycin and efficacy of Esomeprazole-Amoxicilin-Clarithromycin (EAC) regimen in Helicobacter pylori positive duodenal ulcer. Determinate the recrudescence and reinfection status of Helicobacter pylori after successful eradication treatment, by PCR-RFLP technique and UreC gene sequencing.

27p kequaidan12 03-06-2021 17 4   Download

objectives: To describe the epidemiologically clinical and biological characteristics of steroid - dependent and steroid - resistant INS in children at the Hai Phong Children’s Hospital. To evaluate the efficacy of the combination of intravenous cyclophosphamide and prednisolone in treatment of steroid - dependent and steroid - resistant INS in children. To describe changes in several immune parameters before and after treatment in these patients.

29p extraenglish 24-05-2021 9 3   Download

Development of anthelmintic resistance has made it essential to develop alternative ways of worm control in animals. One of the most promising approaches is to treat only those animals which require attention in terms of worm management. “FAMACHA” method has facilitated quick identification of Haemaonchus contortus infected sheep and goats without the aid of any laboratory procedures and delivers the treatment only to those who require it.

6p angicungduoc6 22-07-2020 35 4   Download

The study was carried out during 2013-14 in Meerut district of Uttar Pradesh state to focus on the sugarcane growers regarding impact of knowledge on adoption level of IPM practices. The 80 contact farmers were selected as respondents. The study revealed that the maximum knowledge gap was found to be existing in previous crop residues, crop rotation, hand picking of the insect and their destruction, hot air and water treatment, light and pheromone trap, microbial control, use of natural enemies, resistant varieties, biopesticides/ bio-agents, application and dose of different pest etc.

7p chauchaungayxua6 26-06-2020 22 3   Download

The objectives: At least one Bacillus subtilis strain was isolated in some provinces in the Mekong Delta, having probiotic properties such as: ability to produce digestive enzymes (amylase, protease, lipase); resistance to digestive juice (gastric juice and bile acid), ability to adhere to intestinal mucus and resistance to some pathogenic bacteria (S. enterica, E. coli).

28p cotithanh321 06-08-2019 42 3   Download

HIV-1 protease is an important target for treatment of AIDS, and efficient drugs have been developed. However, the resistance and negative side effects of the current drugs has necessitated the development of new compounds with different binding patterns. In this study, nine C-terminally duplicated HIV-1 protease inhibitors were cocrystallised with the enzyme, the crystal structures analysed at 1.8–2.3 A˚ resolution, and the inhibitory activity of the compounds characterized inorder toevaluate the effects of the individual modifications. ...

13p fptmusic 16-04-2013 44 3   Download

We determined differentially expressed genes in HT29 human colon cancer cells, both after short treatment with methotrexate (MTX) and after the resistance to MTX had been established. Screening was performed using Atlas Human Cancer 1.2K cDNA arrays. The analysis was carried out using Atlasimage 2.01 andgenespring6.1 software.

15p awards 05-04-2013 33 1   Download

HIV-1 protease is a pivotal enzyme in the later stages of the viral life cycle which is responsible for the processing and maturation of the virus particle into an infectious virion. As such,HIV-1proteasehasbecomean important target for the treatment ofAIDS, and efficient drugs have beendeveloped. However, negative side effects and fast emerging resistance to the current drugs have necessitated the development of novel chemical entities in order to exploit different phar-macokinetic properties as well as new interaction patterns....

9p awards 05-04-2013 32 2   Download

Monolayer primary cultures of thyroid cells produce, in the presence of insulin, a cytosolic inhibitor of thyroid peroxi-dase (TPO), lacto peroxidase (LPO), horseradishperoxidase (HRPO) and glutathione peroxidase (GPX). The inhibitor, localized in the cytosol, is thermostable and hydrophylic. Itsmolecularmass is less than2 kDa.The inhibitoryactivity, resistant to proteolytic and nucleolytic enzymes, disappears with sodium metaperiodate treatment, as an oxidant of carbohydrates, supporting its oligosaccharide structure....

8p dell39 03-04-2013 40 3   Download

The spontaneous acquisition of resistance to a variety of unrelated cytotoxic compounds has important implications in medical treatment of infectious diseases and anticancer therapy. In the yeast Saccharomyces cerevisiaethis pheno-menon is caused by overexpression of membrane efflux pumps and is called pleiotropic drug resistance. We have found that allelic forms of the genes for the transcription activators Pdr1p and Pdr3p, designated PDR1-12and PDR3-33,respectively, mediate resistance to diazaborine....

8p dell39 03-04-2013 38 3   Download

We have shown that the ABC transporter, multiple drug resistance protein 1 (MDR1, P-glycoprotein) translocates glucosyl ceramide from the cytosolic to the luminal Golgi surface for neutral, but not acidic, gly-cosphingolipid (GSL) synthesis. Here we show that the MDR1 inhibitor, cyclosporin A (CsA) can deplete Gaucher lymphoid cell lines of accumu-lated glucosyl ceramide and Fabry cell lines of globotriaosyl ceramide (Gb3), by preventing de novosynthesis.

12p inspiron33 26-03-2013 40 5   Download

Both microtubule destabilizer and stabilizer agents are important molecules in anticancer therapy. In particular, paclitaxel has been demonstrated to be effective for the treatment of ovarian, breast, and nonsmall cell lung carci-nomas. It has been shown that emergence of resistance against this agent correlates with an increase in the relative abundance of tubulin isoform bIII and that the more recently discovered IDN5390 can be effectively used once resistance has emerged.

10p inspiron33 25-03-2013 51 4   Download

Several lines of evidence suggest that polymerization of the amyloidb-pep-tide (Ab) into amyloid plaques is a pathogenic event in Alzheimer’s disease (AD). Abis produced from the amyloid precursor protein as the result of sequential proteolytic cleavages by b-secretase and c-secretase, and it has been suggested that these enzymes could be targets for treatment of AD.

14p media19 06-03-2013 40 4   Download

Drug resistance is the major obstacle to successful cancer treatment. To understand the mechanisms responsible for drug resistance in tongue can-cer, Tca8113 cells derived from moderately differentiated human tongue squamous cell carcinoma were exposed to stepwise escalated concentrations of pingyangmycin (PYM) to develop the resistant cell line called Tca8113⁄ PYM

13p viettel02 19-02-2013 38 3   Download

Candidainfections have become an increasingly significant problem, mainly because of the widespread nature ofCandidaand drug resistance. There is an urgent need to develop new classes of drugs for the treatment of oppor-tunistic Candidainfections, especially in medically complex patients.

11p cosis54 05-01-2013 37 3   Download