Whole cell

Brain metastasis is common in patients with non-small cell lung cancer (NSCLC) and it is associated with poorer prognosis. Several options to control the secondary brain tumors in the context include chemotherapy, whole-brain radiation, stereotactic surgery, surgery. However, chemotherapy is ineffective to those patients because of poor penetration through the blood-brain barrier. Whole-brain radiation therapy used to be a standard option for brain metastases.

5p vinatisu 29-08-2024 4 1   Download

Nghiên cứu này giúp người đọc hiểu rõ hơn về cách thức thiết kế một vector tái tổ hợp hướng đến mục tiêu phát triển hệ thống xúc tác toàn tế bào (whole-cell biocatalysts), từ đó mở ra nhiều cơ hội tạo ra nhiều cấu trúc plasmid tái tổ hợp khác trong công nghệ protein tái tổ hợp.

5p vipierre 30-09-2023 10 3   Download

Circulating cell-free DNA (cfDNA) in the plasma of cancer patients contains cell-free tumour DNA (ctDNA) derived from tumour cells and it has been widely recognized as a non-invasive source of tumour DNA for diagnosis and prognosis of cancer.

13p vielonmusk 21-01-2022 20 0   Download

The thesis aims to study the chemical composition and survey the biological activity of two species: the lizard (B. laxiflora) and the cow breast (F. hirta). - Isolate and determine the chemical structure of two species of whole lizard (B. laxiflora) and the root of cow breast (F. hirta). Evaluation of some cytotoxic activity, anti-inflammatory activity, anti-proliferation activity on acute bone marrow cell line (OCI-AML) of extracting extracts and of some isolated compounds to orient for Next application studies.

27p xacxuoc4321 11-07-2019 46 4   Download

Despite high vaccination coverage after introduction of whole cell (wP) and acellular pertussis (aP) vaccines, pertussis resurgence has been reported in many countries.

9p nutifooddau 27-01-2019 18 2   Download

Mice expressing a C-terminal fragment of the prion protein instead of wild-type prion protein die from massive neuronal degeneration within weeks of birth. The C-terminal region of PrPc (PrP121–231) expressed in these mice has an intrinsic neurotoxicity to cultured neurones. Unlike PrPSc, which is not neurotoxic to neurones lacking PrPc expression, PrP121–231 was more neurotoxic to PrPc-deficient cells. Human mutations E200K and F198S were found to enhance toxicity of PrP121–231 to PrP-knockout neurones and E200K enhanced toxicity to wild-type neurones.

10p system191 01-06-2013 30 4   Download

Glycosphingolipids (GSLs) were purified from adults and plerocercoids of the tapeworm Diphyllobothrium hottai, and their chemical structures were determined. Total lipid fractions prepared from chloroform/methanol extracts of whole tissues were fractionated successively on ion-exchange chromatography, silicic acid column chromatography, and preparative TLC. The purified GSLs were characterized by methylation analysis, TLC-immunostaining, liquid secondary ion MS, MALDI-TOF MS, and 1H-NMR.

11p research12 01-06-2013 38 4   Download

The oxidant function of pro-apoptotic protein Bax was investigated through heterologous expression in yeast. Direct measurements of fatty acid content show that Bax-expression induces oxidation of mitochondrial lipids. This effect is prevented by the coexpression of Bcl-xL. The oxi-dation actually could be followed on isolated mitochondria as respiration-induced peroxidation of polyunsaturatedcis-parinaric acid and on whole cells as the increase in the amount of thiobarbituric acid-reactiveproducts. ...

11p tumor12 22-04-2013 37 2   Download

A library of random peptide sequences was used to select peptides that inhibit an anti-idiotypic catalytic Ig, immuno-globulin (IgG) 9G4H9, withab-lactamase-like activity. This library displays cyclic heptapeptides on the surface of bac-teriophagesand representsacollectionofupto4.5·10 9 peptides. The first selection step aimed at enriching the lib-rary in species that bind to the whole Ig molecule. The sec-ond stepwas todiscriminate peptides that bind topart of the molecule other than the active site. Selected peptides were then screened by surface plasmon resonance analysis.

7p fptmusic 16-04-2013 41 3   Download

The 2-hydroxycarboxylate transporter (2HCT) family of secondary trans-porters belongs to a much larger structural class of secondary transporters termed ST3 which contains about 2000 transporters in 32 families. The transporters of the 2HCT family are among the best studied in the class. Here we detect weak sequence similarity between the N- and C-terminal halves of the proteins using a sensitive method which uses a database con-taining the N- and C-terminal halves of all the sequences in ST3 and involves blastsearches of each sequence in the database against the whole database. ...

11p awards 06-04-2013 31 4   Download

A key limitation of whole-cell redox biocatalysis for the production of valuable, specifically functionalized products is substrate⁄product toxicity, which can potentially be overcome by using solvent-tolerant micro-organ-isms.

12p vinaphone15 28-02-2013 46 3   Download

In recent years, a considerable amount of research has been focused on estab-lishing the epigenetic mechanisms associated with DNA and the core histones. This effort is driven by the fact that epigenetics is intimately involved with genomics in a whole range of molecular processes. However, there is now a consensus that the epigenetics of the linker histones are just as important.

13p viettel02 22-02-2013 45 5   Download

A cDNA library from tobacco inoculated withRhizoctonia solaniwas con-structed, and several cDNA fragments were identified by differential hybridization screening. One cDNA clone that was dramatically repressed, NtKTI1, was confirmed as a member of the Kunitz plant proteinase inhibi-tor family. RT-PCR analysis revealed that NtKTI1was constitutively expressed throughout the whole plant and preferentially expressed in the roots and stems.

13p viettel02 19-02-2013 34 4   Download

Previous studies have suggested that microRNAs (miRNAs) may play important roles in tumorigenesis, but little is known about the functions of most miRNAs in cancer development. In the present study, we set up a cell-based screen using a luciferase reporter plasmid carrying the whole 4.7 kb 3¢-UTR of estrogen receptor a(ERa) mRNA cotransfected with a synthetic miRNA expression library to identify potential ERa-targeting miRNAs.

11p mobifone23 18-01-2013 63 4   Download

- Polysaccharides are macromolecules, polymers with a few hundred to a few thousand monosaccharides joined by glycosidic linkages. - Some polysaccharides serve as storage material, hydrolyzed as needed to provide sugar for cells. - Other polysaccharides serve as building material for structures that protect the cell or the whole organism. - The architecture and function of a polysaccharide are determined by its sugar monomers and by the positions of its glycosidic linkages.

118p zingzing09 21-10-2012 54 8   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Formulation of a killed whole cell pneumococcus vaccine - effect of aluminum adjuvants on the antibody and IL-17 response...

10p thulanh27 13-12-2011 34 3   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Segmentation-based detection of allelic imbalance and loss-of-heterozygosity in cancer cells using whole genome SNP arrays...

0p thulanh20 12-11-2011 51 3   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: From single cells to whole organisms...

3p thulanh20 10-11-2011 44 3   Download

Instead of using the fill handle to create a series, you can use Excel’s Series command to gain a little more control over the whole process. Follow these steps: Thay vì sử dụng công cụ Fill handle để tạo một chuỗi (liên tục), bạn có thể sử dụng lệnh Series của Excel để thực hiện tiến trình này, theo các bước sau đây: 1. Select the first cell you want to use for the series, and enter the starting value. If you want to create a series out of a particular pattern (such as 2, 4, 6, and so on), fill...

10p yesno123 16-09-2011 187 65   Download

Approach to the Patient: Gastrointestinal Bleeding Measurement of the heart rate and blood pressure is the best way to assess a patient with GIB. Clinically significant bleeding leads to postural changes in heart rate or blood pressure, tachycardia, and, finally, recumbent hypotension. In contrast, the hemoglobin does not fall immediately with acute GIB, due to proportionate reductions in plasma and red cell volumes (i.e., "people bleed whole blood"). Thus, hemoglobin may be normal or only minimally decreased at the initial presentation of a severe bleeding episode. ...

4p ongxaemnumber1 29-11-2010 60 3   Download