Nicotine

Epidemiological and animal studies have reported that prenatal nicotine exposure (PNE) leads to obesity and type-2 diabetes in offspring. Central leptin-melanocortin signaling via hypothalamic arcuate proopiomelanocortin (POMC) neurons is crucial for the regulation of energy and glucose balance.

27p vioraclene 31-03-2024 3 2   Download

This study aimed to develop and validate an HPLC-PDA method for simultaneous quantification of three compounds: Nicotinamide mononucleotide (NMN), nicotinic acid, and niacinamide in dietary supplements.

12p vigojek 02-02-2024 1 1   Download

Part 2 book "Small animal toxicology" includes content: Poisonous lizards; macadamia nuts; mercury; metaldehyde; methanol; methylxanthines - caffeine, theobromine, theophylline; metronidazole; mushrooms; mycotoxins; nicotine; nonsteroidal antiinflammatories; organochlorine pesticides; organophosphate and carbamate insecticides; oxalate containing plants; paraquat; atypical topical spot on products,... and other contents.

410p muasambanhan03 02-01-2024 3 2   Download

As a human tumor disease, head and neck squamous cell carcinoma (HNSCC) is associated with a high mortality rate worldwide. Nicotinic acetylcholine receptors (nAChRs) are transmembrane receptor proteins and exert their biological effects following activation by nicotine. We aimed to construct a prognostic signature based on the expression of nAChRs among smokers with HNSCC.

12p vileonardodavinci 23-12-2023 5 3   Download

The study was conducted to determine the prevalence of adolescent smoking in Hanoi city in 2023 and the perception of adolescents toward adverse impacts of tobacco. The piece of research was a cross-sectional study, using quantitative methods.

8p vigeorge 06-12-2023 2 1   Download

These devices are generally used to deliver nicotine through inhalation by aerosolization. While the longterm risk of lung cancer is yet to be known, the chemicals and impurities in the solutions may have other acute and chronic effects on the respiratory system including respiratory failure from adult respiratory distress syndrome.

6p viintuit 26-09-2023 2 0   Download

Fresh meat preparations, as fresh sausages, hamburger, minced meats etc, are susceptible to rapid oxidation and the consequent browning of meat red color compromises the product attractiveness. As a result for the producers, there is the drastic reduction of products shelf-life. In order to remedy such economic loss, the addition of some substances with antioxidant effect may represent a valid solution.

6p viisac 23-09-2023 1 1   Download

The clinical recognition of acute lung disease caused by electronic cigarette (e-cigarette) usage has continued to grow. The identified pulmonary pathologies each include some degree of injury and/or inflammation. Electronic cigarettes contain chemicals that hold potential for acute pulmonary toxicity, including, but not limited to, nicotine, volatile organic compounds, and aldehydes.

4p viwhitewolf 03-07-2023 3 2   Download

Non-coding single nucleotide polymorphisms within the nicotinic acetylcholine receptor alpha 4 subunit gene (CHRNA4) are robustly associated with various neurological and behavioral phenotypes including schizophrenia, cognition and smoking.

7p vinarcissa 21-03-2023 1 1   Download

This study investigated whether polymorphisms of the ankyrin repeat and kinase domain containing 1 gene (ANKK1), which is adjacent to the dopamine D2 receptor gene (DRD2), and the dopamine transporter (SLC6A3) and cytochrome P450 2A6 (CYP2A6) genes influence smoking cessation and nicotine dependence in a Japanese population.

9p vinarcissa 21-03-2023 2 1   Download

The aim of this study was to determine if variable number of tandem repeats (VNTR) in the second intron (STin2) of the serotonin transporter (SLC6A4) gene was associated with tobacco use disorder, successful smoking cessation, or smoking characteristics.

9p vinarcissa 21-03-2023 1 1   Download

Cox-regression-based methods have been commonly used for the analyses of survival outcomes, such as age-at-disease-onset. These methods generally assume the hazard functions are proportional among various risk groups. However, such an assumption may not be valid in genetic association studies, especially when complex interactions are involved. In addition, genetic association studies commonly adopt case-control designs.

11p vinarcissa 21-03-2023 4 1   Download

Mục tiêu của tài liệu "Tập huấn về tư vấn và điều trị cai nghiện thuốc lá cho cán bộ y tế" là giúp các bạn đọc có thể mô tả thực trạng sử dụng thuốc lá trên thế giới và trong nước, ảnh hưởng của việc sử dụng thuốc lá đối với sức khỏe và lợi ích của việc cai thuốc; Giải thích nguyên nhân sinh học, tâm lý và xã hội của phụ thuộc thuốc lá và tiến triển của việc nghiện thuốc lá; Mô tả điều trị phụ thuộc thuốc lá bao gồm tư vấn, điều trị dùng thuốc và kết hợp cả hai; Mô tả nguyên lý của truyền thông trực tiếp.

273p bapnuong06 07-03-2023 3 3   Download

Bài viết Sự giao tiếp chéo giữa nicotine và PACAP trong điều hòa tính thèm ăn ở vùng dưới đồi của chuột nhắt trình bày việc sử dụng kết hợp các nghiên cứu dược lý như biểu hiện quá mức có chọn lọc của PACAP, knock-down gen PACAP ở vùng giữa bụng dưới đồi và đánh giá thức ăn thu nhận ở chuột nhắt.

9p viargus 20-02-2023 1 1   Download

Bài viết Ảnh hưởng của thuốc lá điện tử chứa nicotin lên khả năng vận động và sinh sản trên mô hình ruồi giấm thực nghiệm được nghiên cứu nhằm đánh giá tác động do tiếp xúc với nicotin trong thuốc lá điện tử đến sự phát triển từ thế hệ bố mẹ đến thế hệ F1 trên mô hình ruồi giấm Drosophila melanogaster.

6p vidudley 20-02-2023 4 1   Download

The thesis is structured as follows: In Chapter 1, the scientific literature is summarized within the scope of this study. Chapter 2 provides a comprehensive overview of the principles of the applied computational approaches in this study. Chapter 3 identifies the important residues of the LsIA/α7 nAChR complex that affect the interactions between the toxin and the membrane protein due to C-terminal carboxylation of LsIA. The effects of C-terminal modification of LsIA on interactions with α3β2 nAChR, involved in cardiovascular diseases, were also investigated in Chapter 4.

234p runthenight04 02-02-2023 5 2   Download

The combination of four iso-nicotinate appended tetrathiacalix[4]arene (TCA-1) in 1,2-alternate imposed conformation behaving as neutral tectons with Co(II)Cl2 and Hg(II)Cl2 metallic salts, leads to the formation of neutral, new coordination networks. Indeed, the tetrasubstituted TCA-1 derivative leads to a 1D coordination polymer with Co(II)Cl2 and a 2D grid-like network with, Hg(II)Cl2 . The effect of the nature of the metal used on the dimensionality was demonstrated by X-ray diffraction studies on a single crystal.

9p lyhuyenthu 31-01-2023 3 2   Download

For smokers not intending to quit, switching to a reduced-risk nicotine product should be healthier than continuing smoking. We estimate the health impact, over the period 2000–2050, had the nicotine pouch ZYN hypothetically been introduced into the US in 2000. ZYN’s toxicant profile and method of use is like that for Swedish snus, a product with known health effects much less than smoking.

11p viferrari 28-11-2022 3 2   Download

This systematic review therefore seeks to identify the instruments in the field that are designed to assess various aspects of e-cigarette use or its related constructs and analyze the evidence presented regarding the psychometric properties of the identified instruments

21p viferrari 28-11-2022 9 2   Download

This includes group-based support delivered by trained lay local community facilitators (CFs) and free nicotine replacement therapy (NRT). The intervention was pilot tested in a cluster randomised controlled trial, ‘We Can Quit 2’. This paper reports on the WCQ2 process evaluation which assessed feasibility and acceptability of the programme and trial processes.

14p viferrari 28-11-2022 7 2   Download