Báo cáo khoa học: A novel N-terminal hydrophobic motif mediates constitutive degradation of serum- and glucocorticoidinduced kinase-1 by the ubiquitin–proteasome pathway
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Serum- and glucocorticoid-induced protein kinase-1 (SGK-1) plays a crit-ical role in regulation of the epithelial sodium channel, ENaC. SGK-1 also shares significant catalytic domain homology with protein kinase B (PKB⁄AKT-1) and is a downstream effector of antiapoptotic phosphoinos-itide 3-kinase signaling.
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