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Báo cáo khoa học: C-terminal, endoplasmic reticulum-lumenal domain of prosurfactant protein C – structural features and membrane interactions
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Surfactant protein C (SP-C) constitutes the transmembrane part of prosurf-actant protein C (proSP-C) and isa-helical in its native state. The C-termi-nal part of proSP-C (CTC) is localized in the endoplasmic reticulum lumen and binds to misfolded (b-strand) SP-C, thereby preventing its aggregation and amyloid fibril formation.
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