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Báo cáo khoa học: The distinct nucleotide binding states of the transporter associated with antigen processing (TAP) are regulated by the nonhomologous C-terminal tails of TAP1 and TAP2

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:16

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The transporter associated with antigen processing (TAP) delivers peptides into the lumen of the endoplasmic reticu-lum for binding onto major histocompatibility complex class I molecules. TAP comprises two polypeptides,TAP1 andTAP2,eachwithanN-terminal transmembranedomain and a C-terminal cytosolic nucleotide binding domain (NBD). The two NBDs have distinct intrinsic nucleotide binding properties.

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Nội dung Text: Báo cáo khoa học: The distinct nucleotide binding states of the transporter associated with antigen processing (TAP) are regulated by the nonhomologous C-terminal tails of TAP1 and TAP2

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