Báo cáo khoa học: Chaperone and antichaperone activities of trigger factor
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Reduced denatured lysozyme tends to aggregate at neutral pH and competition between productive folding and aggregation substantially reduces the efficiency of refolding. Trigger factor, a folding catalyst and chaperone can, depending on the concentration of trigger factor and the solution conditions, cause either a substantial increase (chaperoneactivity) or a substantial decrease (antichaperone activity) in the recoveryof native lysozymeas comparedwith spontaneous refolding.
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