Báo cáo khoa học: DNA-dependent protein kinase is involved in heat shock protein-mediated accumulation of hypoxia-inducible factor-1a in hypoxic preconditioned HepG2 cells
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Hypoxic preconditioning may afford protection against subsequent lethal hypoxia. As hypoxic tolerance induces changes in the expression of genes involved in DNA damage and repair response pathways, we investigated whether DNA-dependent protein kinase (DNA-PK), one of the DNA dou-ble-strand break repair proteins, could be involved in hypoxic precondi-tioning-induced protective signaling cascades.
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