Báo cáo khoa học: Drosophila melanogaster lipins are tissue-regulated and developmentally regulated and present specific subcellular distributions
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Lipins constitute a novel family of Mg 2+ -dependent phosphatidate phos-phatases that catalyze the dephosphorylation of phosphatidic acid to yield diacylglycerol, an important intermediate in lipid metabolism and cell signaling. Whereas a single lipin is detected in less complex organisms, in mammals there are distinct lipin isoforms and paralogs that are differen-tially expressed among tissues.
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