Báo cáo khoa học: Identification and characterization of eukaryotic initiation factor 5A-2
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The phylogenetically conserved eukaryotic translation initi-ation factor 5A(eIF5A) is the onlyknown cellular protein to contain thepost-translationallyderivedaminoacidhypusine [N e -(4-amino-2-hydroxybutyl)lysine]. Both eIF5A and its hypusine modification are essential for sustained cell proli-feration. Normally only one eIF5A protein is expressed in human cells. Recently, we identified a second humanEIF5A gene that would encode an isoform (eIF5A-2) of 84% sequence identity.
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