Báo cáo khoa học: Interactions of the antimicrobial b-peptide b-17 with phospholipid vesicles differ from membrane interactions of magainins
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We have studied the interaction ofb-17, a potent synthetic antimicrobialb-peptide, with phospholipids. We find that unlikeother antimicrobial peptides suchasmagainin II,b-17 facilitates the formation of nonbilayer phases, indicating that the peptide promotes negative curvature. Studies of liposomal leakage also indicate a different mode of mem-brane interaction relative to magainin II, but both leakage andmembrane binding showthatb-17, likemagainin II, has strongaffinity formembranes containinganionic lipids....
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