Báo cáo khoa học: Lpe10p modulates the activity of the Mrs2p-based yeast mitochondrial Mg2+channel

Saccharomyces cerevisiaeLpe10p is a homologue of the Mg 2+ -channel-forming protein Mrs2p in the inner mitochondrial membrane. Deletion of MRS2, LPE10or both results in a petite phenotype, which exhibits a respi-ratory growth defect on nonfermentable carbon sources. Only coexpression ofMRS2andLPE10leads to full complementation of the mrs2D⁄lpe10D double disruption, indicating that these two proteins cannot substitute for each other.