Báo cáo khoa học: Molecular cloning and functional expression of the human sodium channel b1B subunit, a novel splicing variant of the b1 subunit
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The voltage gated sodiumchannel comprises apore-forming asubunit and regulatory bsubunits. We report here the identificationandcharacterizationof anovel splicingvariant of the humanb1 subunit, termed b1B. The 807 bp open reading frame of the human b1Bsubunit encodes a 268 residue protein with a calculated molecular mass of 30.4 kDa. The novel humanb1B subunit shares an identical N-terminal half (residues 1–149) with the humanb1subunit, but contains a novel C-terminal half (residues 150–268) of less than 17%sequence identity with the humanb1 subunit....
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