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Báo cáo khoa học: Mutational analyses of human eIF5A-1 – identification of amino acid residues critical for eIF5A activity and hypusine modification
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The eukaryotic translation initiation factor 5A (eIF5A) is the only protein that contains hypusine [N e -(4-amino-2-hydroxybutyl)lysine], which is required for its activity. Hypusine is formed by post-translational modifica-tion of one specific lysine (Lys50 for human eIF5A) by deoxyhypusine syn-thase and deoxyhypusine hydroxylase.
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