Báo cáo khoa học: Protein database searches using compositionally adjusted substitution matrices
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Almost all protein database search methods use amino acid substitution matrices for scoring, optimizing, and assessing the statistical significance of sequence alignments. Much care and effort has therefore gone into con-structing substitution matrices, and the quality of search results can depend strongly upon the choice of the proper matrix. A long-standing problem has been the comparison of sequences with biased amino acid composi-tions, for which standard substitution matrices are not optimal....
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