Báo cáo khóa học: The PAS fold A redeﬁnition of the PAS domain based upon structural prediction

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:11

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In the postgenomic era it is essential that protein sequences are annotated correctly in order to help in the assignment of their putative functions. Over 1300 proteins in current pro-tein sequence databases are predicted to contain a PAS domainbaseduponaminoacid sequence alignments.Oneof theproblemswith the current annotationof thePASdomain is that this domain exhibits limited similarity at the amino acid sequence level. It is therefore essential, when using proteins with low-sequence similarities, to apply profile hidden Markov model searches for the PASdomain-con-tainingproteins, as for thePFAMdatabase....

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