Báo cáo khoa học: Regulation of the human leukocyte-derived arginine aminopeptidase/endoplasmic reticulum-aminopeptidase 2 gene by interferon-c
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The leukocyte-derived arginine aminopeptidase (L-RAP) is the second ami-nopeptidase localized in the endoplasmic reticulum (ER) processing anti-genic peptides presented to major histocompatibility complex (MHC) class I molecules. In this study, the genomic organization of the gene encoding human L-RAP was determined and the regulatory mechanism of its expres-sion was elucidated. The entire genomic structure of the L-RAPgene is similar to both placental leucine aminopeptidase (P-LAP) and adipocyte-derived leucine aminopeptidase(A-LAP) genes, confirming the close relation-ship of these three enzymes. ...
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