Báo cáo khoa học: Regulation of the muscle-specific AMP-activated protein kinase a2b2c3 complexes by AMP and implications of the mutations in the c3-subunit for the AMP dependence of the enzyme
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The AMP-activated protein kinase is an evolutionarily conserved hetero-trimer that is important for metabolic sensing in all eukaryotes. The muscle-specific isoform of the regulatory c-subunit of the kinase, AMP-activated protein kinasec3, has a key role in glucose and fat metabolism in skeletal muscle, as suggested by metabolic characterization of humans, pigs and mice harboring substitutions in the AMP-binding Bateman domains ofc3.
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