Báo cáo khoa học: Role of conformational flexibility for enzymatic activity in NADH oxidase from Thermus thermophilus
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NADHoxidase fromThermus thermophilusis a homodimer with anunknownphysiological function. As is typical for an enzyme isolated froma thermophile,the catalytic rate,kcat,is low at low temperatures and increases with temperature, achieving an optimum at the physiological temperature of the organism,i.e. at 70CforT. thermophilus.Atlow temperatures,thekcatof several enzymes from thermophilic and mesophilic organisms can be increased by chaotropic agents.
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