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Báo cáo khoa học: Solution NMR structure of a human FGF-1 monomer, activated by a hexasaccharide heparin-analogue
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The 3D structure of a complex formed by the acidic fibroblast growth fac-tor (FGF-1) and a specifically designed synthetic heparin hexasaccharide has been determined by NMR spectroscopy. This hexasaccharide can sub-stitute natural heparins in FGF-1 mitogenesis assays, in spite of not indu-cing any apparent dimerization of the growth factor.
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