Báo cáo khoa học: Subcellular localization of yeast Sec14 homologues and their involvement in regulation of phospholipid turnover
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Sec14p of the yeastSaccharomyces cerevisiaeis involved in protein secretion and regulation of lipid synthesis and turnover in vivo, but acts as a phosphatidylinositol–phos-phatidylcholine transfer proteinin vitro. In this work, the five homologues of Sec14p, Sfh1p–Sfh5p, were subjected to biochemical andcell biological analysis toget abetter viewof their physiological role. We show that overexpression of SFH2andSFH4suppressed thesec14growth defect in a more andSFH1in a less efficient way, whereas overexpres-sion ofSFH3andSFH5did not complementsec14....
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