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Báo cáo khoa học: Sumoylation of a meiosis-specific RecA homolog, Lim15/Dmc1, via interaction with the small ubiquitinrelated modifier (SUMO)-conjugating enzyme Ubc9
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Sumoylation is a post-translational modification system that covalently attaches the small ubiquitin-related modifier (SUMO) to target proteins. Ubc9 is required as the E2-type enzyme for SUMO-1 conjugation to tar-gets. Here, we show that Ubc9 interacts with the meiosis-specific RecA homolog, Lim15⁄Dmc1 in the basidiomyceteCoprinus cinereus(CcLim15), and mediates sumoylation of CcLim15 during meiosis.
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