Báo cáo khoa học: The Mycobacterium tuberculosis ORF Rv0654 encodes a carotenoid oxygenase mediating central and excentric cleavage of conventional and aromatic carotenoids
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Mycobacterium tuberculosis, the causative agent of tuberculosis, is assumed to lack carotenoids, which are widespread pigments fulfilling important functions as radical scavengers and as a source of apocarotenoids. In mam-mals, the synthesis of apocarotenoids, including retinoic acid, is initiated by theb-carotene cleavage oxygenases I and II catalyzing either a central or an excentric cleavage of b-carotene, respectively.
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