Báo cáo khoa học: The potent inhibitory activity of histone H1.2 C-terminal fragments on furin
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Many physiologically important proproteins, pathogenic bacterial exo-toxins and viral envelope glycoproteins are activated by the proprotein con-vertase furin, which makes furin inhibitor a hot target for basic research and drug design. Although synthetic and bioengineered inhibitors of furin have been well characterized, its endogenous inhibitor has not been directly purified from mammalian tissues to date.
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