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Báo cáo khóa học: The zinc-binding site of a class I aminoacyl-tRNA synthetase is a SWIM domain that modulates amino acid binding via the tRNA acceptor arm

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:10

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In its tRNA acceptor end binding domain, the glutamyl-tRNA synthetase (GluRS) of Escherichia colicontains one atom ofzinc that holds the extremities ofa segment (Cys98-x-Cys100-x24-Cys125-x-His127) homologous to the Escherichia coliglutaminyl-tRNA synthetase (GlnRS) loop where a leucine residue stabilizes the peeled-back conformation of tRNA Gln acceptor end. We report here that the GluRS zinc-binding region belongs to the novel SWIM domain family characterized by the signature C-x-C-xn-C-x-H (n¼6–25),...

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Nội dung Text: Báo cáo khóa học: The zinc-binding site of a class I aminoacyl-tRNA synthetase is a SWIM domain that modulates amino acid binding via the tRNA acceptor arm

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