
Báo cáo Y học: The C-terminal region of ammodytoxins is important but not sufficient for neurotoxicity
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Ammodytoxins (Atxs) are presynaptically acting snake venom phospholipase A2 (PLA2) toxins the molecular mechanism of whose neurotoxicity is not completely understood. Two chimeric PLA2s were prepared by repla-cing the C-terminal part of a nontoxic venom PLA2 , ammodytin I2, with that of AtxA(K108N). The chimeras were not toxic, but were able to bind strongly to an Atxs-specific neuronal receptor, R25.
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