Biodegradable gellan gum hydrogels loaded with paclitaxel for HER2+ breast cancer local therapy

Hydrogels loaded with chemotherapeutics are promising tools for local tumor treatment. In this work, redoxresponsive implantable hydrogels based on gellan gum were prepared as paclitaxel carriers for HER2-positive breast cancer therapy. To achieve different degrees of chemical crosslinking, hydrogels were synthesized in both acetate buffer and phosphate buffer and crosslinked with different concentrations of L-cysteine.