Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 7)
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Clinical Presentation and Diagnosis The spectrum of clinical severity of HS is broad. Severe cases may present in infancy with severe anemia, whereas mild cases may present in young adults or even later in life. In women, HS is sometimes first diagnosed when anemia is investigated during pregnancy. The main clinical findings are jaundice, an enlarged spleen, and often gallstones; frequently it is the finding of gallstones in a young person that triggers diagnostic investigations. The variability in clinical manifestations that is observed among patients with HS is largely due to the different underlying molecular lesions (Table 101-3). Not only...
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