The synthesis of new oxindoles as analogs of natural product 3,3′ -bis(indolyl)oxindole and in vitro evaluation of the enzyme activity of G6PD and 6PGD

Natural and synthetic derivatives that contain an indole core are being used in medical treatments and technological processes. Therefore, the development of new synthetic methods for the synthesis of indole derivatives is very popular. In this study, new oxindoles with reaction of 4,7-dihydro-1H -indole (2) and isatin (4) were synthesized as analogs of natural product 3,3′ -bis(indolyl)oxindole. The biological properties of the compounds obtained during this study were also studied, showing that compounds 5, 7, and 12 inhibited the activity of G6PD with an IC50 of 99 µM, 231 µM, and 304 µM respectively.