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Cationic channels
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Breast cancer is the most common female tumors arising worldwide, and genetic and epigenetic events are constantly accumulated in breast tumorigenesis. The melastatin-related transient receptor potential 7 channel (TRPM7) is a nonselective cation channel, mainly maintaining Zn2+, Ca2+ and Mg2+ homeostasis. It is also involved in regulating proliferation and migration in various cancers including breast cancer.
10p
vialfrednobel
23-12-2023
5
4
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YNU-5 zeolite has the YFI-type framework with a 12-12-8-ring system (2-dimensional 12-oxygen membered ring pores 3-dimensionally connected by twin 8-ring channels), and isolated 8-ring channels separated from the system by a thin (mono-atomic silicate) wall. In this study, the acidic property of YNU-5 zeolite was analyzed mainly by means of the ammonia IRMS-TPD (infrared/mass spectroscopy temperature-programmed desorption) method.
12p
vironald
15-12-2022
2
2
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The cyclic nucleotide-gated ion channel (CNGC) family affects the uptake of cations, growth, pathogen defence, and thermotolerance in plants. However, the systematic identification, origin and function of this gene family has not been performed in Brassica oleracea, an important vegetable crop and genomic model organism.
18p
vilarryellison
29-10-2021
5
0
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Members of the transient receptor potential (TRP) superfamily are proteins that are critical for insects to detect changes in environmental stimuli and also play key roles in their sensory physiology. Moreover, this family provides potential targets for the design of insecticides.
13p
vitzuyu2711
29-09-2021
19
1
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Understanding viral infection of the olfactory epithelium is essential because the olfactory nerve is an important route of entry for viruses to the central nervous system. Specialized chemosensory epithelial cells that express the transient receptor potential cation channel subfamily M member 5 (TRPM5) are found throughout the airways and intestinal epithelium and are involved in responses to viral infection.
20p
vilichoo2711
23-06-2021
12
1
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Defective phagocytosis in alveolar macrophages is associated with chronic obstructive pulmonary disease (COPD). Transient receptor potential cation channel subfamily V member 2 (TRPV2), a type of nonselective cation channel pertinent to diverse physiological functions, regulates macrophage phagocytosis.
10p
vimaine2711
26-03-2021
17
2
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The method of density functional theory using B3P86/6-311+G(d) functional/basis set have been performed for searching stable structures and preferable dissociation channels of the doubly vanadium-doped silicon cationic clusters SinV2 + (n = 1 - 8).
8p
tamynhan9
02-12-2020
3
1
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Accordingly, in the second stage-game, “broadcasting firms face a trade-off: either they capture large audiences by keeping the advertising rate low, or they stuff programs with advertising interruptions, thereby losing audience in favour of their competitor” (Vaglio, p. 35). Thus, the second stage-game in which advertising rates are decided, closely resembles the second stage-game of a spatial competition model in which, after having decided about their lo- cation, firms decide about their prices.
0p
dambaotaikhoan
06-05-2013
85
5
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As CDT measurement is not available within Scotland, it is recommended only when there is clinical difficulty in interpreting a normal or an abnormal GGT or other liver test result. Kings College Hospital, London accept serum samples by post for CDT assay. Biological tests are of less value than self reports for screening with the intention of intervention. They have their greatest role where patients have a reason for minimising (or, less commonly, exaggerating) their consumption, and in monitoring patients progress in reducing their drinking.
70p
seketnoi
26-04-2013
30
1
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A novel peptidyl inhibitor of voltage-gated K + channels, named parabutoxin 3 (PBTx3), has been puri®ed to homo-geneity from the venom ofParabuthus transvaalicus.This scorpion toxin contains 37 residues, has a mass of 4274 Da and displays 41% identity with charybdotoxin (ChTx, also called Ôa-KTx1.1Õ). PBTx3 is the tenth member (called Ôa-KTx1.10Õ)ofsubfamily1ofK + channel-blocking pep-tidesknown thus far.
12p
research12
23-04-2013
48
2
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The vanilloid-like TRP-channel VRL-1 (TRPV2) is a non-selective cation channel expressed by primary sensory neurons and non-neuronal tissues [Caterina, M.J., Rosen, T.A., Tominaga, M., Brake, A.J and Julius, D. (1999) Nature398, 436–441]. It is one of the six members of the vanilloid-like TRP-channel family which is now termed the TRPV family [Montell, G., Birnbaumer, L., Flockerzi, V., Bindels, R.J., Brutford, E.A., Caterina, M.J., Clapham, D.E., Harteneck, C., Heller, S., Julius, D., Kojima, I., Mori, Y., Penner, R., Prawitt, D., Scharenberg, A.M., Schultz, G., Shimizu, N. and Zhu, M.X.
8p
tumor12
20-04-2013
27
2
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Clarification requests (CRs) in conversation ensure and maintain mutual understanding and thus play a crucial role in robust dialogue interaction. In this paper, we describe a corpus study of CRs in task-oriented dialogue and compare our findings to those reported in two prior studies. We find that CR behavior in task-oriented dialogue differs significantly from that in everyday conversation in a number of ways. Moreover, the dialogue type, the modality and the channel quality all influence the decision of when to clarify and at which level of the grounding process. ...
8p
bunbo_1
17-04-2013
36
2
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Scorpion toxins that affect sodium channel (NaCh) gating in excitable cells are divided into a-andb-classes. Whereas a-toxinshavebeen found inscorpions throughout theworld, anti-mammalianb-toxins have been assigned, thus far, to New World scorpions while anti-insect selective b-toxins (depressant and excitatory) have been described only in the Old World. 2 This distribution suggested that diversification ofb-toxins into distinct pharmacological groups occurred after the separation of the continents, 150 million years ago....
8p
fptmusic
16-04-2013
26
2
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The biological ion channel gramicidin A (gA) was modified by synthetic means to obtain the tail-to-tail linked asymmetric gA-derived dimer com-pound3. Single-channel current measurements for 3in planar lipid bilayers exhibit an Eisenman I ion selectivity for alkali cations. The structural asymmetry does not lead to an observable functional asymmetry. The structure of 3in solution without and with Cs cations was investigated by 1 H-NMR spectroscopy. In CDCl3 ⁄CD3OH (1 : 1, v⁄v),3forms a mixture of double-strandedb-helices....
12p
awards
05-04-2013
29
1
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Endovanilloids are defined as endogenous ligands of the transient receptor potential vanilloid type 1 (TRPV1) protein,a nonselective cation channel that belongs to the large family of TRP ion channels,and is activated by the pungent ingredient of hot chilli peppers,capsaicin. TRPV1 is expressed in some nociceptor efferent neurons, where it acts as a molecular sensor of noxious heat and low pH. However,the presence of these channels in var-ious regions of the central nervous system,where they are not likely to be targeted by these noxious stimuli,suggests the existence of endovanilloids.
8p
dell39
03-04-2013
41
2
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Cone snails, a group of gastropod animals that inhabit tropical seas, are capable of producing a mixture of peptide neurotoxins, namely conotoxins, for defense and predation. Conotoxins are mainly disulfide-rich short pep-tides that act on different ion channels, neurotransmitter receptors, or transporters in the nervous system.
12p
media19
06-03-2013
37
1
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Brain serine racemase contains pyridoxal phosphate as a prosthetic group and is known to become activated by divalent cations such as Ca 2+ and Mg2+ , as well as by ATP and ADP. In vivo, brain serine racemase is also activated by a multi-PSD-95⁄discs large⁄ZO-1 (PDZ) domain glutamate receptor interacting protein (GRIP) that is usually coupled to the GluR2⁄3 subunits of the a-amino-3-hydroxy-5-methylisoxazole-4-propionic acid Ca 2+ channel.
11p
media19
04-03-2013
56
5
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P2X receptors are cation-selective ion channels activated by extracellular ATP. They form homo- and heterotrimeric complexes that differ in their functional properties and subcellular localization. These membrane ion channels are also expressed in pulmonary epithelial cells.
13p
vinaphone15
27-02-2013
31
1
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Besides being activated by G-proteinb⁄c subunits, G-protein activated potassium channels (GIRKs) are regulated by cAMP-dependent protein kinase. Back-phosphorylation experiments have revealed that the GIRK1 subunit is phosphorylatedin vivo upon protein kinase A activation inXeno-pusoocytes, whereas phosphorylation was eliminated when protein kinase A was blocked.
9p
viettel02
20-02-2013
30
1
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A number of studies (see, for example, Iacoviello (2005) or Calza et al (2009)) apply the nancial accelerator to the housing market, where a similar mechanism is at work. A reduction in interest rates increases the value of collateral (housing) by increasing the discounted value of future user costs. The borrowers' debt capacity and consequently the demand for housing increases further, generating an even larger increase in house prices. Persistence and amplication would be mutually reinforcing and propagate the effect of the initial shock to interest rates on housing activity.
47p
taisaovanchuavo
23-01-2013
48
5
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