CD4 cells
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Adenosine monophosphate-activated protein kinase (AMPK) is associated with the development of liver hepatocellular carcinoma (LIHC). AMPKα2, an α2 subunit of AMPK, is encoded by PRKAA2, and functions as the catalytic core of AMPK. However, the role of AMPKα2 in the LIHC tumor immune environment is unclear.
17p vikoch 27-06-2024 2 1 Download
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Ebook "T helper cell differentiation and their function" will focus on the differentiation and regulation of subsets of CD4+ T cells. It will also cover other aspects of research on these cells, which has made great advances in recent years, such as subsets’ plasticity and their role in healthy and disease conditions. The book provides researchers and graduate students with a cutting-edge and comprehensive overview of essential research on CD4+ T cells.
237p tracanhphuonghoa1007 22-04-2024 4 1 Download
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Traditionally, the transcriptomic and proteomic characterisation of CD4+ T cells at the single-cell level has been performed by two largely exclusive types of technologies: single-cell RNA sequencing (scRNA-seq) and antibody-based cytometry.
22p vibransone 28-03-2024 6 2 Download
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Systemic sclerosis (SSc) is a genetically complex autoimmune disease mediated by the interplay between genetic and epigenetic factors in a multitude of immune cells, with CD4+ T lymphocytes as one of the principle drivers of pathogenesis.
17p vibransone 28-03-2024 3 2 Download
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The Wiskott–Aldrich syndrome protein (WASp) family of actin-nucleating factors are present in the cytoplasm and in the nucleus. The role of nuclear WASp for T cell development remains incompletely defined. Methods: We performed WASp chromatin immunoprecipitation and deep sequencing (ChIP-seq) in thymocytes and spleen CD4+ T cells.
18p vioraclene 31-03-2024 7 1 Download
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Immunoglobulin G4-related disease (IgG4-RD) and systemic sclerosis (SSc) are rare autoimmune diseases characterized by the presence of CD4+ cytotoxic T cells in the blood as well as inflammation and fibrosis in various organs, but they have no established etiologies.
14p vibransone 28-03-2024 4 2 Download
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Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma (CTCL). CTCL are an uncommon, heterogeneous group of non-Hodgkin lymphomas (NHLs) of T- and B-cell origin where the skin is the primary organ of involvement. It is characterized by malignant CD4+ T-cells inflating the skin and other organs, leading to progressive skin and systemic involvement.
10p vitiki 30-01-2024 4 2 Download
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Ebook "The biology of dendritic cells and HIV infection" focuses on the role of DCs in the pathogenesis and immunity of HIV-1 infection. It has recently been clarified that DCs are important targets and reservoirs of HIV and may play an important role in virus spreading to T cells. Interestingly, HIV can exploit many of the cellular processes responsible for the generation and regulation of the adaptive immune responses to gain access to its main target cells, i.e. the CD4+ T lymphocytes.
562p tachieuhoa 28-01-2024 3 2 Download
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Biomarkers that can accurately predict the efcacy of immune checkpoint inhibitors (ICIs) against programmed death 1 (PD-1) ligand in cancer immunotherapy are urgently needed. We have previously reported a novel formula that predicts the response to treatment with second-line nivolumab with high sensitivity and specificity in patients with non-small cell lung cancer (NSCLC) previously treated with chemotherapy.
10p vileonardodavinci 23-12-2023 6 3 Download
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Tregs are able of suppressing tumor-specific efector cells, such as lymphocytes CD8+, CD4+ and Natural Killer cells. Different drugs, especially different schedules of administration, like metronomic chemotherapy (mCHT), seem to be able to increase anticancer immunity, by acting on downregulation of Tregs.
10p vialfrednobel 23-12-2023 5 3 Download
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Bệnh bạch cầu tế bào lympho T lớn có hạt (T-Cell Large Granular Lymphocytic Leukemia – T-LGLL) là một phân nhóm trong u lympho tế bào T/NK trưởng thành. T-LGLL được đặc trưng bởi sự tăng sinh đơn dòng của các tế bào lympho lớn có hạt trong máu ngoại biên kéo dài >6 tháng.
6p vibranson 06-12-2023 8 3 Download
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Polysaccharides have aroused considerable interest due to their diverse biological activities and low toxicity. In this study, we evaluated the effect of marine polysaccharide sulfated polymannuroguluronate (TGC161) on the leukopenia induced by chemotherapy.
12p viginny 30-12-2022 7 2 Download
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Immunotherapy has become a new therapy for advanced hepatocellular carcinoma (HCC); however, its treatment results are considerably different. CD4+ T cells (CD4+) are the key to immunotherapy, but patients with HCC that have low CD4+ are rarely observed for clinical evidence.
10p vikolindagrabar 27-07-2022 3 1 Download
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There is a paucity of data regarding the prognostic influence of peripheral blood CD4+ T lymphopenia in non-small cell lung cancer (NSCLC). Therefore, we investigated the prognostic value of T lymphopenia in NSCLC.
11p vikolindagrabar 27-07-2022 3 1 Download
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There are different subsets of T regulatory cells (Tregs), orchestrating critical roles in the regulation of anti-tumor immunity in colorectal cancer (CRC). In this study, we report that a high frequency of circulating CD4+FoxP3+ Tregs was associated with poorer disease-free survival (DFS), while their higher frequencies in tumour-infltrating CD4+ Tregs was associated with better DFS.
13p visusanwojcicki 28-06-2022 7 2 Download
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Autoimmune disease-associated variants are preferentially found in regulatory regions in immune cells, particularly CD4+ T cells. Linking such regulatory regions to gene promoters in disease-relevant cell contexts facilitates identification of candidate disease genes.
19p vialfrednobel 29-01-2022 6 0 Download
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Differentiation of lymphocytes is frequently accompanied by cell cycle changes, interplay that is of central importance for immunity but is still incompletely understood. Here, we interrogate and quantitatively model how proliferation is linked to differentiation in CD4+ T cells.
15p viaristotle 29-01-2022 10 0 Download
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Blood transfusion can cause immunosuppression and lead to worse outcomes in patients with digestive tract malignancies; however, the specific mechanism behind this is not completely understood. One theory is that increased numbers of regulatory CD3+ CD4+ CD25+ FOXP3+ T cells (Tregs) and forkhead box protein-3 mRNA (FOXP3) expression in the blood after transfusion contribute to these outcomes.
9p vidietmarhopp 29-12-2021 11 0 Download
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Mutant peptides presented by MHC (major histocompatibility complex) Class II in cancer are important targets for cancer immunotherapy. Both animal studies and clinical trials in cancer patients showed that CD4 T cells specific to tumor-derived mutant peptides are essential for the efficacy of immune checkpoint blockade therapy by PD1 antibody.
9p vitzuyu2711 29-09-2021 10 1 Download
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Transcriptome profiling of human thymic CD4+ and CD8+ T cells compared to primary peripheral T cells
The thymus is a highly specialized organ of the immune system where T cell precursors develop and differentiate into self-tolerant CD4+ or CD8+ T cells. No studies to date have investigated how the human transcriptome profiles differ, between T cells still residing in the thymus and T cells in the periphery.
15p vijeeni2711 24-07-2021 11 0 Download