Clinical trials

AD/CAM hybrid ceramic restorations have been developed enormously in recent years. This study aimed to evaluate the treatment outcomes of CAD/CAM hybrid ceramic overlays (Shofu HC). A prospective, descriptive clinical trial study has been conducted on 30 permanent posterior teeth with cavities that need to be restored by overlay. All 30 teeth were prepared and restored by CAD/CAM hybrid ceramic overlays (Shofu disc HC).

6p viormkorn 27-09-2024 2 1   Download

Green tea consumption has been shown to exhibit cancer-preventive activities in preclinical studies. Polyphenon E (Poly E) is a green tea standardized extract. This study was undertaken to examine the antiproliferative effect and pro-oxidant activity of Poly E on PC3 prostate cancer cells.

5p vifaye 20-09-2024 1 1   Download

Drug therapy to achieve the recommended target blood pressure remains the cornerstone of the management of hypertension. Today, there are strong evidences from randomized controlled trials that antihypertensive drugs are more effective than placebo at reducing cardiovascular mortality and morbidity.

8p vifaye 20-09-2024 2 0   Download

Periodontitis is the most common form of periodontal disease, greatly affecting the aesthetics, function as well as patient’s quality of life. In the periodontal disease treatment strategy, nonsurgical treatment is considered as the initial phase for anti-infection and soft-tissue management. This study aims to compare the effect of two nonsurgical periodontal modalities: one-stage full-mouth and partial-mouth protocols for periodontitis.

7p vifaye 20-09-2024 3 1   Download

The aim was to evaluate the effectiveness of chronic periodontitis treatment using the diode laser method in Odonto - Stomatology Department of Friendship Hospital. Subjects and methods: Our study was a case-control clinical trial. Sixty patients were randomized into two groups. The group of controls 30 patients with chronic periodontitis who were treated with conventional procedures (cleaning and polishing).

6p viyoko 20-09-2024 2 1   Download

This pioneer trial aimed to evaluate the effectiveness of using ketamine plus atropine as anaesthetic agents for paediatric oncology procedures. From this study, we establish a protocol for anaesthesia in paediatric oncology procedures.

5p vinatisu 29-08-2024 4 1   Download

This study aimed to determine the incidence of postoperative nausea and vomiting among parturients receiving sub-hypnotic dose of propofol or dexamethasone as prophylaxis after cesarean section under intrathecal morphine to extend post-operative analgesia and the side effects of these drugs on patients.

6p vinatisu 29-08-2024 7 1   Download

Multiple screening tools exist but the length of the examination and the false positive rate range from good to adequate. A screening tool was designed and tested in the emergency department using nurse responders without a scoring system.

5p vinatisu 29-08-2024 4 1   Download

This study aims to compare niche incidence between single- and double-layer uterine closure techniques and describe related factors among women with full-term primary C-section. From May 2022 to March 2023 at Hanoi Obstetrics and Gynecology Hospital, a double-blind, randomized controlled trial was performed on 116 participants (64 in single- and 52 women in double-layer group).

11p vinatisu 23-08-2024 2 1   Download

Older patients are underrepresented in the clinical trials that determine the standards of care for oncological treatment. We conducted a review to identify whether there have been age-restrictive inclusion criteria in clinical trials over the last twenty five years, focusing on patients with metastatic gastroesophageal cancer.

9p vielonmusk 21-01-2022 12 1   Download

Safety and efficacy of immune checkpoint inhibitors in advanced gastric or gastroesophageal junction (GEJ) cancer could be demonstrated in predominantly Asian cohorts, whereas data in Western patients outside of clinical trials are vastly missing.

10p vielonmusk 21-01-2022 16 0   Download

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer mortality in the world. Therefore, more and more studies are developing novel therapies to treat this disease. The pre-clinical trials on animals are a vital step to evaluate the efficacy as well as side effects of these novel therapies. Hence, this study aimed to develop the murine model of HCC using 3 kinds of mice: NOD/SCID, nude and Balb/c mice.

7p larachdumlanat127 02-01-2021 14 2   Download

Evaluating shaping result of ProTaper Next and ProTaper Universal system when performed on upper premolars’ root canal of the elderly. Evaluating shaping result of ProTaper Next and ProTaper Universal system when performed on upper premolars’ root canal of the elderly.

29p cothumenhmong6 17-07-2020 11 3   Download

AR-42, a new orally bioavailable, potent, hydroxamate-tethered phenylbutyrate class I/IIB histone deacetylase inhibitor currently is under evaluation in phase 1 and 2 clinical trials and has demonstrated activity in both hematologic and solid tumor malignancies. This report focuses on the preclinical characterization of the pharmacokinetics of AR-42 in mice and rats.

9p caothientrangnguyen 09-05-2020 18 3   Download

Staphylokinase (SAK) is a 15.5-kDa protein fromStaphy-lococcus aureusthat activates plasminogenby forminga1 : 1 complex with plasmin. Recombinant SAK has been shown in clinical trials to induce ®brin-speci®c clot lysis in patients withacutemyocardial infarction.However, SAKelicits high titers of neutralizing antibodies. Biochemical and protein engineering studies have demonstrated the feasibility of generatingSAKvariantswith reducedantigenicity yet intact thrombolytic potency.

7p research12 23-04-2013 41 3   Download

Onconase, a member of the ribonuclease superfamily, is a potent cytotoxicagent that isundergoingphase II/IIIhuman clinical trials as an antitumor drug. Native onconase from Rana pipiensand its amphibian homologs have an N-ter-minal pyroglutamyl residue that is essential for obtaining fully active enzymes with their full potential as cytotoxins. When expressed cytosolically in bacteria, Onconase is isolated with an additional methionyl (Met1) residue and glutaminyl insteadof a pyroglutamyl residue at position 1 of the N-terminus and is consequently inactivated....

9p dell39 03-04-2013 33 4   Download

Several ribonucleases, including onconase anda-sarcin, are known to be toxic to tumor cells. On the other hand, although its structure is relatedto thatofa-sarcin,RNase T1 is noncytotoxic because of its inability to internalize into tumor cells. In this study, we internalized RNase T1 into human tumor cells via a novel gene transfer reagent, hem-agglutinating virus of Japan (HVJ) envelope vector, which resulted in cell death.

6p dell39 03-04-2013 37 5   Download

Because clinical trials of pharmacological neuroprotective strategies in stroke have been disappointing, attention has turned to the brain’s own endogenous strategies for neuroprotection. Two endogenous mechanisms have been characterized so far, namely ischemic preconditioning and ische-mic postconditioning.

12p vinaphone15 27-02-2013 33 2   Download

Stroke is the third leading cause of death in industrialized countries but efficacious stroke treatment is still an unmet need. Preclinical research indi-cates that different molecules afford protection from ischemic neurodegen-eration, but all clinical trials conducted so far have inexorably failed.

10p vinaphone15 27-02-2013 36 1   Download

Onconase  (ONC) is a member of the ribonuclease A superfamily that is toxic to cancer cells in vitro andin vivo. ONC is now in Phase IIIb clinical trials for the treatment of malignant mesothelioma. Internalization of ONC to the cytosol of cancer cells is essential for its cytotoxic activity, despite the apparent absence of a cell-surface receptor protein.

12p vinaphone15 25-02-2013 28 3   Download