Control drugs

Amlodipine is a representative active ingredient of calcium channel blockers. In addition to the general advantages of calcium channel blockers in treating hypertension, amlodipine also effectively controls blood pressure for 24 hours and has no or just a little effect on neurohormonal activation, so it does not cause high blood pressure at the last dose. However, amlodipine has a plasma half-life of between 30 and 40 hours, slowing the drug's action duration.

9p viakimichi 17-01-2025 4 2   Download

Drug therapy to achieve the recommended target blood pressure remains the cornerstone of the management of hypertension. Today, there are strong evidences from randomized controlled trials that antihypertensive drugs are more effective than placebo at reducing cardiovascular mortality and morbidity.

8p viharuno 03-01-2025 2 2   Download

Drug resistant tuberculosis (DR-TB) remains a global health problem. The diagnosis, treatment, and management of DR-TB are the major challenges to Vietnam National Tuberculosis Control Program. One of the most important solutions for overcoming this problem is developing reliable and low-cost methods, which have been proposed to Drug Susceptibility Testing (DST) to detect drug resistant tuberculosis.

6p viharuno 03-01-2025 16 2   Download

Intracranial infection (abscess) - usually staphylococci or streptococci. Cranial surgery performed to open and drain abscess. Epilepsy - Cranial surgery to remove the epileptic focus for patients whose epilepsy cannot be controlled by drug therapy. Skull fractures - for depressed fracture or fracture with loose fragments. Cranial surgery necessary to elevate depressed bone and/or remove fragments.

38p littledragon89 10-08-2011 97 25   Download

At the end of the session, participants should be able to: understand the complexity of drugs and classification of the drugs, define the society and understand the relation between drugs and society, understand the various interventions that can be used to mediate the impact of drugs on society.

43p tuoihaimuoi32 19-06-2014 75 5   Download

Cisplatin (CP) is considered one of the most effective and widely used anti-neoplastic drug in the treatment of different solid organ tumors. The present study was carried out to assess the hematological changes following CP administration in Wistar albino rats and its amelioration by extract of Andrographis paniculata (AP). The study included 60 Wistar albino rats were divided into 12 rats in each group. Group I served as normal control group.

8p angicungduoc6 22-07-2020 11 2   Download

Quantifying the multiple processes which control and modulate the extent of oral bioavailability for drug candidates is critical to accurate projection of human pharmacokinetics (PK). Understanding how gut wall metabolism and hepatic elimination factor into first-pass clearance of drugs has improved enormously. Typically, the cytochrome P450s, uridine 5′- diphosphate-glucuronosyltransferases and sulfotransferases, are the main enzyme classes responsible for drug metabolism. Knowledge of the isoforms functionally expressed within organs of first-pass clearance, their anatomical topology (e.

16p caothientrangnguyen 09-05-2020 20 1   Download

Schistosomiasis is an endemic disease in Egypt caused by the trematode Schistosoma which has different species. c the best known form of chronic disease with a wide range of clinical manifestations. The pathogenesis of schistosomiasis is related to the host cellular immune response. This leads to granuloma formation and neo angiogenesis with subsequent periportal fibrosis manifested as portal hypertension, splenomegaly and esophageal varices. Intestinal schistosomiasis is another well identified form of chronic schistosomal affection.

8p kethamoi1 17-11-2019 30 2   Download

Purpose: Based on theoretical studies of state management on the prevention of drugs, analysis and assessment of the state of the state management on the prevention of drugs in Vietnam, fellows establish and implement the scientific foundation to propose practical solutions to improve system ef ciency of state management on the prevention of drugs in Vietnam during the integration period.

28p change01 05-05-2016 52 4   Download

Mẫu giấy phép nhập khaur bằng tiếng anh - Import licence MINISTRY OF PUBLIC SECURITY Social Republic of VIETNAM Standing Office on Crime and Drugs Control -------IMPORT LICENCE --------------- No. ............................. Hanoi, date......................................... Standing Office on Crime and Drugs Control of ministry of Public Security here by certify that: Institute of Forensic Science, Ministry of Public Security Being the authority charged with the administration of the relating to the drugs to with the 1961, 1971, 1988 conventions apply: ...

1p banhbeonhanthit 31-07-2013 88 7   Download

Theb-amyloid peptide (Ab) is a major component of toxic amyloid plaques found in the brains of patients with Alzheimer’s disease.Abis liberated by sequential cleavage of amyloid precursor protein (APP) byb-andc-secre-tases.The level of Abdepends directly on the hydrolytic activity ofb-secretase.Therefore, b-secretase is an excel-lent target for drug design.An approach based on RNA-cleaving ribozymes was developed to control expression ofb-secretase.

9p tumor12 20-04-2013 38 4   Download

The spontaneous acquisition of resistance to a variety of unrelated cytotoxic compounds has important implications in medical treatment of infectious diseases and anticancer therapy. In the yeast Saccharomyces cerevisiaethis pheno-menon is caused by overexpression of membrane efflux pumps and is called pleiotropic drug resistance. We have found that allelic forms of the genes for the transcription activators Pdr1p and Pdr3p, designated PDR1-12and PDR3-33,respectively, mediate resistance to diazaborine....

8p dell39 03-04-2013 38 3   Download

In the search for new drug targets in the human parasite Entamoeba histolytica, metabolic control analysis was applied to determine, experimen-tally, flux control distribution of amebal glycolysis. The first (hexokinase, hexose-6-phosphate isomerase, pyrophosphate-dependent phosphofructo-

16p galaxyss3 07-03-2013 52 4   Download

L-3,4-Dihydroxyphenylalanine (L-dopa) remains the most effective phar-macological treatment for relief of the severe motor impairments of Par-kinson’s disease. It is very effective in controlling parkinsonian symptoms in the initial phase of the disease, but its action wanes with time. Such ‘wearing-off’ imposes an escalation in the dosage of the drug, which ulti-mately fails to provide stable control of motor symptoms and results in the appearance of abnormal involuntary movements or dyskinesia....

8p media19 06-03-2013 35 3   Download

Of the fourPlasmodiumspecies that cause human malaria,Plasmodium fal-ciparumis responsible for the most severe form of the disease and this par-asite is developing resistance to the major antimalarial drugs. Therefore, in order to control malaria it is necessary to identify new drug targets.

6p media19 04-03-2013 29 2   Download

Despite intensive research extending back to the 1930s, when the first syn-thetic antimalarial drugs made their appearance, the repertoire of clinically licensed formulations remains very limited. Moreover, widespread and increasing resistance to these drugs contributes enormously to the difficul-ties in controlling malaria, posing considerable intellectual, technical and humanitarian challenges.

11p media19 04-03-2013 39 2   Download

Many protein substrates of caspases are cleaved at noncanonical sites in comparison to the recognition motifs reported for the three caspase sub-groups. To provide insight into the specificity and aid in the design of drugs to control cell death, crystal structures of caspase-7 were determined in complexes with six peptide analogs (Ac-DMQD-Cho, Ac-DQMD-Cho, Ac-DNLD-Cho, Ac-IEPD-Cho, Ac-ESMD-Cho, Ac-WEHD-Cho) that span the major recognition motifs of the three subgroups.

14p media19 04-03-2013 40 4   Download

Tuberculosis (TB) continues to be a major cause of morbidity and mortal-ity worldwide. The increasing emergence and spread of drug-resistant TB poses a significant threat to disease control and calls for the urgent devel-opment of new drugs. The tryptophan biosynthetic pathway plays an important role in the survival of Mycobacterium tuberculosis.

11p vinaphone15 27-02-2013 51 2   Download

Polymeric micelle, the self-assembly of block copolymers with core-shell architecture, is a promising nanocarrier for drug and gene delivery. There are several relevant properties in polymeric micelle as nanocarrier systems, such as longevity in blood circula-tion, tissue-penetrating ability, spatial and temporal controlled drug release, and reduced inherent toxicity of cytotoxic reagents.

6p viettel02 22-02-2013 47 2   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Research Article Continuous Drug Infusion for Diabetes Therapy: A Closed-Loop Control System Design

10p sting10 24-02-2012 48 7   Download