Corticotropin

Bài viết trình bày mô tả một số đặc điểm lâm sàng và cận lâm sàng của bệnh nhân suy thượng thận mạn tính do lạm dụng corticosteroid ở Khoa Nội 3, Bệnh viện Hữu nghị Việt Tiệp năm 2023; Nhận xét các yếu tố nguy cơ mắc bệnh liên quan đến đường dùng, liều dùng và thời gian dùng thuốc corticosteroid ở các đối tượng nghiên cứu trên.

8p viwalton 02-07-2024 8 2   Download

A new human/rat CRH analogue has been synthesized using the Fmoc/tBu solid-phase synthetic protocol. The sequence ofthe new peptide differs from the original in two positions, 12 and 15, at which the native amino acids L-phenylalanine 12 and L-leucine 15 have been replaced by the nonprotein amino acids D-phenylalanine and a-aminoisobutyric acid (Aib), respectively. The high resolution three-dimensional solution structure of [D-Phe12, Aib15]CRH has been determined by 688 dis-tance constraints (656 meaningful NOE and 32 H-bonds distance limits) and 21 angle constraints. ...

11p tumor12 22-04-2013 34 3   Download

Anovel photoactivatable analog of antisauvagine-30 (aSvg-30), a specific antagonist for corticotropin-releasing factor (CRF) receptor, type 2 (CRF2), has been synthesized and characterized. TheN-terminal amino-acidD-Phe in aSvg-30 [D-Phe11,His12]Svg(11)40) was replacedbyaphenyldiazirine, the 4-(1-azi-2,2,2-trifluoroethyl)benzoyl (ATB) residue.

7p tumor12 22-04-2013 31 3   Download

The corticotropin releasing factor receptor 1 (CRFR1) belongs to the superfamily of G-protein coupled receptors. Though CRF is involved in the aetiology of several stress-relateddisorders, includingdepressionandanxiety, detailsof CRFR1 regulation such as internalization remain unchar-acterized. In the present study, agonist-induced internal-ization of CRFR1 in HEK293 cells was visualized by confocal microcopy and quantified using the radioligand 125 I-labelled sauvagine.

0p awards 05-04-2013 32 3   Download

In our continued studies on corticotropin releasing factor receptor (CRFR1) signaling in the skin, we tested functional activity of CRFR1a, e, f, g and h isoforms after transfection to COS cells.Both membrane-bound and soluble variants are translatedin vivointofinal proteinproducts that undergo further post-translational modifications.

10p dell39 03-04-2013 40 3   Download

Rarely, corticotropin-releasing hormone (CRH) is produced by pancreatic islet tumors, SCLC, medullary thyroid cancer, carcinoids, or prostate cancer. When levels are high enough, CRH can cause pituitary corticotrope hyperplasia and Cushing's syndrome. Tumors that produce CRH sometimes also produce ACTH, raising the possibility of a paracrine mechanism for ACTH production. A distinct mechanism for ACTH-independent Cushing's syndrome involves ectopic expression of various G protein–coupled receptors in the adrenal nodules.

5p thanhongan 07-12-2010 66 3   Download

Adrenocortical steroids and their synthetic analogues Mechanisms of action Actions: mineralocorticoid, glucocorticoid Individual adrenal steroids Pharmacokinetics Dosage schedules Choice of adrenal steroid Adverse effects of systemic pharmacotherapy Adrenal steroids and pregnancy Precautions during chronic therapy: treatment of intercurrent illness Dosage and routes of administration Indications for use Uses: replacement therapy, pharmacotherapy Withdrawal of pharmacotherapy . Inhibition of synthesis of adrenal steroids. Competitive antagonism .

17p bigbaby87 03-09-2010 79 13   Download