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Dna damage response
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Uveal melanoma (UVM) is the most common primary intraocular tumor in adults, with a median survival of 4–5 months following metastasis. DNA damage response (DDR) upregulation in UVM, which could be linked to its frequent activation of the PI3K/AKT pathway, contributes to its treatment resistance.
11p
vishanshan
27-06-2024
1
1
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Ebook "Necrotic cell death" presents comprehensive coverage of necrosis from recognized experts from leading academic and medical institutions around the world. In contrast to apoptosis, well-defined as a form of programmed cell death, necrosis used to be considered as accidental (i.e., non-programmed) cell death, usually in response to a severe injury. Accumulating evidence now suggests, however, that necrosis is also programmed and controlled by distinctive "death machinery" in response to various stimuli like oxidative stress or DNA damage.
402p
ladongphongthanh1008
22-04-2024
3
1
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Exosomes are promising tools for improving cancer care, but conversely may also contribute to tumor progression. Here, we highlight recently discovered roles of exosomes in modulating immune responses in cancer, with emphasis on exosomal surface proteins and on RNA and DNA content. We also discuss how exosomes could be exploited as biomarkers and delivery vehicles in cancer therapy.
4p
vibransone
28-03-2024
2
2
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Ebook "Cell death: Mechanism and disease" provides a comprehensive view of cell death, from its mechanisms of initiation and execution, to its implication in human disease and therapy. Physiological cell death plays critical roles in almost all aspects of biology, and the book details its roles in lymphocyte homeostasis, neuronal function, metabolism, and the DNA damage response. When physiological cell death goes awry, diseases can arise, and cancer is presented as a central paradigm for the consequences of derangements in the interplay between cell survival and cell death.
280p
manmanthanhla0201
26-02-2024
2
1
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Ebook "Aluminum stress adaptation in plants (Signaling and communication in plants, Volume 24)" is an overview of our current understanding of aluminium toxicity and tolerance in plants. It covers all relevant aspects from molecular and cellular biology, to genetic approaches, root biology and plant physiology. The contribution of arbuscular mycorrhizal fungi to alleviating aluminium toxicity is also discussed. Over 40% of total agricultural land resources are acidic in nature, with aluminium being the major toxicant.
280p
manmanthanhla0201
26-02-2024
8
1
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AZD0156 is an oral inhibitor of ATM, a serine threonine kinase that plays a key role in DNA damage response (DDR) associated with double-strand breaks. Topoisomerase-I inhibitor irinotecan is used clinically to treat colorectal cancer (CRC), often in combination with 5-fluorouracil (5FU).
13p
vialfrednobel
23-12-2023
6
3
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DCLRE1B is a 5’-to-3’ exonuclease, which is involved in repairing ICL-related DNA damage. DCLRE1B has been reported to cause poor prognosis in a variety of cancers. Nonetheless, there is no research on DCLRE1B’s biological role in pan-cancer datasets. Thus, ascertaining the processes via which DCLRE1B modulates tumorigenesis was the goal of the extensive bioinformatics investigation of pan-cancer datasets in the present research.
14p
vialfrednobel
23-12-2023
5
3
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To analyze the incidence and risk of hypertension associated with poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors in cancer patients and provide reference for clinicians.
17p
vischultz
20-10-2023
2
1
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Genomic alterations, including loss of function in chromosome band 11q22-23, are frequently observed in neuroblastoma, which is the most common extracranial childhood tumour. In neuroblastoma, ATM, a DNA damage response-associated gene located on 11q22-23, has been linked to tumorigenicity.
13p
vischultz
20-10-2023
1
1
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To investigate how Fusobacterium nucleatum (Fn) promotes oxidative stress and mediates proliferation and autophagy in hypopharyngeal squamous cell carcinoma (HPSCC). The prognosis for 82 HPSCC cases was retrospectively analyzed. HPSCC cell line FaDu was co-cultured with Fn. Knockdown of NUDT1 (shNUDT1 group) was done after observing DNA damage response.
14p
visharma
20-10-2023
6
2
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The role of ATF2 in colon cancer (CC) is controversial. Recently, we reported that low ATF2 expression is characteristic of highly invasive tumors, suggesting that ATF2 might also be involved in therapy resistance. 5-Fluoro-uracil (5-FU) is the best-known chemotherapeutic drug for CC, but drug resistance affects its curative effect.
15p
visharma
20-10-2023
5
2
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Endometrial cancer (EC) arises from uterine endometrium tissue and is the most prevalent cancer of the female reproductive tract in developed countries. It has been predicted that the global prevalence of EC will increase in part because of its positive association with economic growth and lifestyle.
15p
visharma
20-10-2023
4
2
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Inhibitors of Poly (ADP-Ribose) Polymerases (PARP) provide clinical benefit to patients with breast and ovarian cancers, by compromising the DNA repair activity of cancer cells. Although these agents extend progressionfree survival in many patients, responses can be short lived with many patients ultimately progressing.
14p
vioracle
29-09-2023
4
2
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In this study, we investigated the protection of EGCG for DNA single strand breaks in irradiated cells using primers for amplification of RNA polymerase, an enzyme responsible to synthesis of mRNA from the damaged DNA, through its down-regulated capacity.
4p
vidumbledore
06-01-2023
10
2
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An important motivation for the use of nanomaterials and nanoarchitectures in cancer therapy emanates from the widespread emergence of drug resistance. Although doxorubicin (DOX) induces cell cycle arrest and DNA damage by suppressing topoisomerase activity, resistance to DOX has severely restricted its anti-cancer potential.
21p
viginny
30-12-2022
7
2
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The WW domain-containing oxidoreductase (WWOX) tumor suppressor gene is frequently lost in a variety of solid and hematopoietic malignancies in humans. Dysregulation of WWOX has been implicated as playing a key role in tumor cell survival, DNA damage repair, and genomic stability.
13p
vigandhi
23-02-2022
8
1
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This pilot investigation has indicated that sub-lethal waterborne Sb(III) exposure manifests in genotoxic effects in freshwater fish species, which may have consequences for resilience and survival. Further study is needed for deeper insight into the relationship between Sb(III) and genotoxicity and the multiple biomarker responses that need assessment to evidence effects.
10p
thebadguys
15-01-2022
8
0
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Radiotherapy is routinely used to combat glioblastoma (GBM). However, the treatment efficacy is often limited by the radioresistance of GBM cells. Two GBM lines MO59K and MO59J, differing in intrinsic radiosensitivity and mutational status of DNA-PK and ATM, were analyzed regarding their response to DNA-PK/PI3K/mTOR inhibition by PI-103 in combination with radiation.
20p
vimahuateng
26-11-2021
6
2
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In this study, we evaluated the cytotoxic activity of a novel naphthoquinone-derived compound (1,4-naphthoquinone (1,4-NQ)) against two different breast cancer cells: a hormone-responsive cell line (MCF-7) and a triple-negative cell line (MDA-MB-231). As a result, 1,4-NQ decreased cell viability in both tested cell lines in a dose-dependent manner. Increased apoptotic markers (presence of pyknotic nuclei, annexin-V positivity, caspase 3/7 activity, and decreased mitochondrial membrane potential) and DNA damage were especially observed in MDA-MB-231 cells after treatment with the compound.
8p
thiencuuchu
27-11-2021
20
0
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Autophagy and DNA repair are two essential biological mechanisms that maintain cellular homeostasis. Impairment of these mechanisms was associated with several pathologies such as premature aging, neurodegenerative diseases, and cancer. Intrinsic or extrinsic stress stimuli (e.g., reactive oxygen species or ionizing radiation) cause DNA damage. As a biological stress response, autophagy is activated following insults that threaten DNA integrity.
18p
thiencuuchu
27-11-2021
8
1
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