Drug interactions

Tyrosine kinase inhibitors are increasingly used in the treatment of cancer. Drug interactions involving tyrosine kinase inhibitors are commonly encountered in clinical practice. To analyze DDI between TKIs and the concomitant medication.

8p viling 11-10-2024 1 0   Download

Building a list of contraindicated drug interactions and evaluating the initial results of applying information technology to prevent contraindicated drug interactions in prescriptions at the Military Hospital 7.

5p viohoyo 02-04-2024 6 3   Download

The presence of heterocyclic moiety in diverse compounds, strongly indicative of the desired effect on physiological activity, and it reflects on efforts to find useful synthetic drugs.

12p tocectocec 25-05-2020 16 1   Download

Porous metal organic framework nanoscale carriers as a potential platform for drug delivery and imaging, In the domain of health, one important challenge is the efficient delivery of drugs in the body using non-toxic nanocarriers. Most of the existing carrier materials show poor drug loading and or rapid release of the proportion of the drug that is simply adsorbed at the external surface of the nanocarrier.

7p hotrotaitailieu 30-03-2016 74 1   Download

In this communication, we report the synthesis of chitosan (CS, a biodegradable and biocom- patible natural polymer) [1] nanoparticles as drug carriers by ionic gelation. The method is based on ionic interactions between positively charged groups NH3 + of CS (in dilute CH3COOH solution) and negatively charged of sodium tripolyphos- phate, TPP).

2p uocvong04 24-09-2015 84 3   Download

The synthesis and characterization of chitosan (CS) nanoparticles used as drug carrier was reported. The formation of nanoparticles, taking place in an aqueous phase without using auxiliary toxic substances via the ionic interaction between NH3 + protonated group of CS and phosphate group of sodium tripolyphosphate (TPP) was monitored in situ by combined UV-vis and pH measurements. The synthesized nanoparticles were characterized by TGA/DTA, XRD and TEM. The particle size, estimated by TEM, was found around 50 - 70 nm, with a quite uniform size distribution.

5p uocvong01 24-09-2015 64 2   Download

Objectives: Identify effects of substance use on HIV outcomes and transmission, Review clinic - based substance use disorder interventions including medication-assisted treatments, Identify drug interactions between medicationassisted treatments and ART, Discuss cases from Hanoi OPCs and MMTs.

54p tuoihaimuoi32 19-06-2014 60 3   Download

Một số thức ăn nguồn gốc thực vật có thể tương tác với chuyển hoá của nhiều thuốc qua cơ chế enzym, hoặc ức chế chuyển hoá của thuốc, hoặc gây c.m ứng enzym, kết qu. của t-ơng tác "thức ăn - thuốc" này có khi có ích, nhưng thường là bất lợi. Nước quả bưởi (viết tắt: nước bưởi) vị hơi đắng, nên có tính gi.i khát. Ngoài vitamin C, nước bưởi còn chứa nhiều chất chống oxy hoá phức tạp (lycopen, limonoid...), lượng lớn pectin....

4p sunshine_6 02-07-2013 80 4   Download

Serotonin transporters are key target sites for clinical drugs and psychostimulants, such as fluoxetine and cocaine. Molecular cloning of a serotonin transporter from the cen-tral nervous system of the insectManduca sextaenabled us to define domains that affect antagonist action, particularly cocaine.

11p research12 23-04-2013 35 1   Download

Liver microsomal preparations are routinely used to predict drug interactions that can occurin vivo as a result of inhi-bition of cytochrome P450 (CYP)-mediated metabolism. However, the concentration of free drug (substrate and inhibitor)at its intrahepatic site of action, a variable that cannot be directly measured, may be significantly different from that in microsomal incubation systems.

10p tumor12 20-04-2013 46 4   Download

Plant flavonoids are polyphenolic compounds, commonly found in vegeta-bles, fruits and many food sources that form a significant portion of our diet. These compounds have been shown to interact with several ATP-bind-ing cassette transporters that are linked with anticancer and antiviral drug resistance and, as such, may be beneficial in modulating drug resistance. This study investigates the interactions of six common polyphenols; querce-tin, silymarin, resveratrol, naringenin, daidzein and hesperetin with the multidrug-resistance-associated proteins, MRP1, MRP4 and MRP5. ...

16p fptmusic 12-04-2013 40 2   Download

The structural changes produced by the minor-groove binding ligand DAPI (4¢,6-diamidine-2-phenylindole) on individual strands of trinucleotide repeat sequences were detectedby electrophoreticband-shift analysis andrelated to their effects on DNA replication in vitro. Among the 20 possible single-stranded trinucleotide repeats, only theT-rich strand of the AATÆATT triplet exhibits an observable fluorescence band and a change in electrophoretic mobility due to the drug binding.

7p fptmusic 12-04-2013 45 4   Download

The structure of the complex between the minor groove binder netropsin and d(GGCCAATTGG) was determined via single-crystal X-ray tech-niques. The structure was refined to completion usingrefmac5.1.24, result-ing in a residual R-factor of 20.0% (including 68 water molecules). Using crystal engineering and cryocooling techniques, the resolution could be enhanced to 1.75 A ˚ , resulting in an unambiguous determination of the drug conformation and orientation.

11p fptmusic 11-04-2013 34 2   Download

HIV-1 protease is a pivotal enzyme in the later stages of the viral life cycle which is responsible for the processing and maturation of the virus particle into an infectious virion. As such,HIV-1proteasehasbecomean important target for the treatment ofAIDS, and efficient drugs have beendeveloped. However, negative side effects and fast emerging resistance to the current drugs have necessitated the development of novel chemical entities in order to exploit different phar-macokinetic properties as well as new interaction patterns....

9p awards 05-04-2013 32 2   Download

INTRODUCTION Contrary to popular belief, pharmacy is not limited to counting and dispensing pills. Pharmacy is a rewarding profession in the health care system that involves working closely with doctors and patients. No matter what health field you step into, there will always be a need for pharmacists. They provide their expertise on the composition, use, and manufacturing of a drug, as well as its physiological and chemical interactions. Pharmacy offers flexible work schedules, a broad spectrum of opportunities, direct patient contact, and top salaries right out of college!...

30p mailan1977 29-03-2013 139 16   Download

Lys101Glu is a drug resistance mutation in reverse transcriptase clinically observed in HIV-1 from infected patients treated with the non-nucleoside inhibitor (NNRTI) drugs nevirapine and efavirenz. In contrast to many NNRTI resistance mutations, Lys101(p66 subunit) is positioned at the sur-face of the NNRTI pocket where it interacts across the reverse transcrip-tase (RT) subunit interface with Glu138(p51 subunit).

11p inspiron33 25-03-2013 28 5   Download

Endogenous and exogenous opiates are currently considered the drugs of choice for treating different kinds of pain. However, their prolonged use produces several adverse symptoms, and in addition, many forms of pain are resistant to any kind of therapy.

23p media19 06-03-2013 49 4   Download

An emerging body of evidence supports a key role for the endocannabinoid system in numerous physiological and pathological mechanisms of the cen-tral nervous system. In the recent past, many experimental studies have examined the putative protective or toxic effects of drugs interacting with cannabinoid receptors or have measured the brain levels of endocannabi-noids inin vitro and in vivo models of cerebral ischemia.

11p vinaphone15 27-02-2013 40 3   Download

The DevR response regulator mediates adaptation ofMycobacterium tuber-culosisto various signals that are likely to be encountered within the host such as hypoxia, nitric oxide, carbon monoxide and ascorbic acid. DevR is proposed as a promising target for developing drugs against dormant bac-teria.

9p cosis54 05-01-2013 38 5   Download

MODELLING AIDS EPIDEMIC AND TREATMENT WITH DIFFERENCE EQUATIONS K. M. TAMIZHMANI, A. RAMANI, B. GRAMMATICOS, AND A. S. CARSTEA Received 15 October 2003 and in revised form 10 March 2004 We propose two models for the description of the dynamics of an AIDS epidemic and of the effect of a combined-drugs AIDS treatment based on difference equations. We show that our interacting population model, despite its extreme simplicity, describes adequately the evolution of an AIDS epidemic. A cellular-automaton analogue of the discrete system of equations is presented as well.

11p sting12 10-03-2012 39 5   Download