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Drug positioning
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Bài giảng Thuốc trợ tim (Positive inotropic drugs), được biên soạn với mục tiêu giúp các bạn học có thể phân loại các thuốc điều trị suy tim; trình bày được cơ chế tác dụng, chỉ định, chống chỉ định, và tác dụng không mong muốn của các nhóm thuốc trợ tim; trình bày các biểu hiện ngộ độc và cách xử trí ngộ độc digitalis. Mời các bạn cùng tham khảo!
18p
thuyduong0620
12-07-2024
1
1
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This research designeded to: 1. Analyze the efficacy and safety of Palbociclib treatment in HR-positive and HER2-negative (HR+/HER2-) metastatic breast cancer(MBC) patients. 2. Establish and validate a nomogram model for predicting the progression-free survival (PFS) rates of 6 months, 12 months, and 18 months in HR+/HER2- MBC patients after receiving Palbociclib plus endocrine therapy (ET).
13p
vishanshan
27-06-2024
2
1
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Novel antibody-drug conjugates (ADCs) drugs present a promising anti-cancer treatment, although survival benefits for HER2-positive advanced breast cancer (BC) remain controversial. The aim of this meta-analysis was to evaluate the comparative effect of ADCs and other anti-HER2 therapy on progression-free survival (PFS) and overall survival (OS) for treatment of HER2-positive locally advanced or metastatic BC.
10p
vikoch
27-06-2024
1
1
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Ebook Interpretation of MS–MS mass spectra of drugs and pesticides includes the following main contents: Provides a general discussion on the fragmentation of even-electron ions (protonated and deprotonated molecules) in both positive-ion and negative-ion modes; This is the reference book for the interpretation of MS–MS mass spectra of small organic molecules; Covers related therapeutic classes of compounds such as drugs for cardiovascular diseases, psychotropic compounds, drugs of abuse and designer drugs, antimicrobials, among many others.
405p
vimeyers
29-05-2024
4
2
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The outcomes are to be compared with typical drugs given that compounds are examined against gram-positive and gram-negative strains of bacteria and fungus. Against bacterial strains, products with nitro, methyl, and bromo substituents in the p-position of the benzene ring, as well as products with the nitro group at the m-position, showed very excellent activities against bacterial strains, while compounds with chloro substituent at p-position and m-position demonstrated good activity against the fungal strains Aspergillus niger and Fusarium javanicum.
8p
dianmotminh02
03-05-2024
2
1
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As a new work searching potential bioactive hybrid derivatives for drug design, where 3-aryl-2-mercaptoquinazolin-4(3H)-one scaffold is incorporated in specific coumarin moiety with or without bearing acetamide group, the synthesis and structure of new hybrid compounds were reported.
6p
dianmotminh02
03-05-2024
2
1
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Ebook "Small molecule therapeutics for schizophrenia" covers all relevant aspects of drug research, e.g.
327p
tracanhphuonghoa1007
22-04-2024
3
3
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To study analgesic effects of basil extracts (Ocimum basilicum L.) on mice. Subjects and methods: The experiments were conducted according to heat stimulation (hot plate) and needle slide methods. In each experiment, mice were divided into 4 groups of 10 each, in which the negative control group was given distilled water, the positive one took the control drug, and the others were treated with basil extracts at the doses of 2.4 and 7.2 g/kg/day for 7 consecutive days.
6p
viohoyo
16-04-2024
3
2
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Based on promising phase II data, the histone deacetylase inhibitor entinostat is in phase III trials for patients with metastatic estrogen receptor-positive breast cancer. Predictors of sensitivity and resistance, however, remain unknown.
14p
vibransone
28-03-2024
5
2
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Drug resistance continues to be a major limiting factor across diverse anti-cancer therapies. Contributing to the complexity of this challenge is cancer plasticity, in which one cancer subtype switches to another in response to treatment, for example, triple-negative breast cancer (TNBC) to Her2-positive breast cancer
17p
viellison
28-03-2024
3
2
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In this study, we introduce a novel method for effecting the direct difluoromethylation at the C-3 position of the quinoline ring. Comprehensive characterizations, including 1 H-NMR, 13C-NMR, and 19F-NMR for all compounds are performed. We believe that this novel method will open a new way to access the hitherto untapped C-3-difluoromethylation active compounds.
6p
viellison
28-03-2024
3
2
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The study aimed to determine the smoking prevalence and explore the association between smoking and viral load among people living with HIV who are drug users (HIV+ PWID) in Vietnam. We used secondary data from a descriptive cross-sectional study of 280 HIV+ PWID in an open-label, non-inferiority trial from July 2015 to February 2018 at six HIV clinics in Northern Vietnam.
10p
vilarry
12-03-2024
4
1
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In ebook "Heteroaromatic lipoxin A4 analogues: Synthesis and biological evaluation" Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious.
143p
nhanphanguyet
28-01-2024
3
2
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Literature has demonstrated hypoglossal nerve stimulation to be a safe and effective treatment for patients with obstructive sleep apnea nonadherent to positive airway pressure therapy. However, the recommended criteria for patient selection are still unable to identify all the unresponsive patients, highlighting the need for improved understanding about hypoglossal nerve stimulation for obstructive sleep apnea.
6p
vitiki
30-01-2024
7
2
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Cancer chemotherapy indications for patients with poor performance status and advanced lung cancer are limited. Molecular targeted drugs, including epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors, can be used in patients with poor performance status owing to their high efcacy and safety.
6p
vileonardodavinci
23-12-2023
3
2
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HER2 expression has a prognostic and predictive impact in early-stage breast cancer (BC). HER2 positive BC (immunohistochemistry (IHC) score 3+or 2+with in situ hybridization (ISH) amplifcation) are treated with HER2 targeted therapies.
10p
vileonardodavinci
23-12-2023
10
4
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Novel ADC drugs provide a new therapeutic strategy for gastric cancer.The present study aimed to analyze the clinical efficacy and drug toxicities of disitamab vedotin (RC48) plus immune checkpoint inhibitors(ICIs) and RC48 as third-line therapies and beyond for advanced and metastatic gastric cancer patients.
8p
vileonardodavinci
23-12-2023
3
3
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This study aimed to explore the efficiency and safety of the new generation antibody-drug conjugate Trastuzumab deruxtecan (DS-8201a) in treating HER2-positive solid cancers. By searching PubMed, Medline and Ovid for all clinical trials related to the safety and efficacy of DS-8201a. Event rates were calculated for all adverse events (AEs) to evaluate the safety of DS-8201a. Objective response rate (ORR) and progression-free survival (PFS) were summarized to assess the potency of DS-8201a.
9p
vialfrednobel
23-12-2023
5
3
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Tregs are able of suppressing tumor-specific efector cells, such as lymphocytes CD8+, CD4+ and Natural Killer cells. Different drugs, especially different schedules of administration, like metronomic chemotherapy (mCHT), seem to be able to increase anticancer immunity, by acting on downregulation of Tregs.
10p
vialfrednobel
23-12-2023
5
3
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Trastuzumab is an important targeted drug for HER2-positive gastric cancer. The treatment efcacy of a more cost-efective and accessible trastuzumab biosimilar, HLX02, was not well investigated, especially when combined with antiangiogenic treatment.
11p
vialfrednobel
23-12-2023
4
3
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