Drug therapy
-
Part 2 book "Pharmaceutical design and development" includes content: Rational design of drugs based on molecular structure, nucleic acid therapies, transgenic animal models, diagnostic applications of biotechnology, future prospects.
104p muasambanhan10 03-04-2024 2 2 Download
-
Part 2 book "Fowler's zoo and wild animal medicine current therapy" includes content: Fish medicine updates, antibiotic resistance in public aquariums, harmful algal blooms, emerging infectious diseases of reptiles, tropical avian diseases, avian hatching assistance, egg necropsies, electrocution of raptors, update on the status of vultures and nonsteroidal antiinflammatory drug regulations,....and other contents.
424p muasambanhan10 03-04-2024 3 1 Download
-
A comprehensive understanding of cancer has been furthered with technological improvements and decreasing costs of next-generation sequencing (NGS). However, the complexity of interpreting genomic data is hindering the implementation of high-throughput technologies in the clinical context: increasing evidence on gene–drug interactions complicates the task of assigning clinical significance to genomic variants.
15p vibransone 28-03-2024 2 2 Download
-
Exosomes are promising tools for improving cancer care, but conversely may also contribute to tumor progression. Here, we highlight recently discovered roles of exosomes in modulating immune responses in cancer, with emphasis on exosomal surface proteins and on RNA and DNA content. We also discuss how exosomes could be exploited as biomarkers and delivery vehicles in cancer therapy.
4p vibransone 28-03-2024 2 2 Download
-
Myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML) are characterised by abnormal epigenetic repression and differentiation of bone marrow haematopoietic stem cells (HSCs). Drugs that reverse epigenetic repression, such as 5-azacytidine (5-AZA), induce haematological improvement in half of treated patients.
18p vibransone 28-03-2024 2 2 Download
-
Bevacizumab, a monoclonal antibody against soluble VEGFA, is an approved and commonly administered anti-angiogenic drug in patients with metastasized colorectal cancer (mCRC). The survival benefit of anti-VEGF therapy in mCRC patients is limited to a few months, and acquired resistance mechanisms are largely unknown.
17p vibransone 28-03-2024 2 2 Download
-
Clear cell renal cell carcinoma (ccRCC) is the dominant subtype of renal cancer. With currently available therapies, cure of advanced and metastatic ccRCC is achieved only in rare cases. Here, we developed a workflow integrating different -omics technologies to identify ccRCC-specific HLA-presented peptides as potential drug targets for ccRCC immunotherapy.
24p vibransone 28-03-2024 1 1 Download
-
Identification of actionable genomic vulnerabilities is key to precision oncology. Utilizing a large-scale drug screening in patient-derived xenografts, we uncover driver gene alteration connections, derive driver co-occurrence (DCO) networks, and relate these to drug sensitivity.
23p vibransone 28-03-2024 3 2 Download
-
Increases in α-synuclein protein expression are suspected to increase the risk of the development of Parkinson’s disease (PD). A recent study has demonstrated that β2-adrenergic receptor (β2AR) agonists decrease histone acetylation in the α-synuclein gene and suppress transcription.
3p vioraclene 31-03-2024 2 2 Download
-
Medulloblastoma (MB) is the most common malignant paediatric brain tumour and a leading cause of cancer-related mortality and morbidity. Existing treatment protocols are aggressive in nature resulting in significant neurological, intellectual and physical disabilities for the children undergoing treatment. Thus, there is an urgent need for improved, targeted therapies that minimize these harmful side effects.
15p vibransone 28-03-2024 2 2 Download
-
While understanding molecular heterogeneity across patients underpins precision oncology, there is increasing appreciation for taking intra-tumor heterogeneity into account. Based on large-scale analysis of cancer omics datasets, we highlight the importance of intra-tumor transcriptomic heterogeneity (ITTH) for predicting clinical outcomes.
14p vibransone 28-03-2024 2 2 Download
-
We present Beyondcell, a computational methodology for identifying tumour cell subpopulations with distinct drug responses in single-cell RNA-seq data and proposing cancer-specific treatments. Our method calculates an enrichment score in a collection of drug signatures, delineating therapeutic clusters (TCs) within cellular populations.
15p vibransone 28-03-2024 1 1 Download
-
Ebook "Nanoparticles in lung cancer therapy - Recent trends" provides an insight into the present scenario of the role of nanotechnology in the diagnosis and treatment of lung cancer at an early stage. Currently, lung cancer is the subject of major concern owing to the very high mortality rate throughout the world. Most of the conventional treatment methods such as surgery, chemotherapy, radiotherapy, etc., fail to prolong life of the patients.
78p tudohanhtau1006 29-03-2024 2 1 Download
-
Drug resistance continues to be a major limiting factor across diverse anti-cancer therapies. Contributing to the complexity of this challenge is cancer plasticity, in which one cancer subtype switches to another in response to treatment, for example, triple-negative breast cancer (TNBC) to Her2-positive breast cancer
17p viellison 28-03-2024 3 2 Download
-
In this study, we introduce a novel method for effecting the direct difluoromethylation at the C-3 position of the quinoline ring. Comprehensive characterizations, including 1 H-NMR, 13C-NMR, and 19F-NMR for all compounds are performed. We believe that this novel method will open a new way to access the hitherto untapped C-3-difluoromethylation active compounds.
6p viellison 28-03-2024 2 2 Download
-
While effective vaccines are being administered globally, there is still a great need for antiviral therapies as antigenically novel SARS-CoV-2 variants continue to emerge across the globe. Viruses require host factors at every step in their life cycle, representing a rich pool of candidate targets for antiviral drug design.
18p viellison 28-03-2024 1 1 Download
-
Ebook "Stem cell biology and regenerative medicine in ophthalmology" provides a comprehensive and engaging overview of the latest innovations in the field. Twelve chapters discuss the fastest growing areas in ophthalmological stem cell research, from disease modelling, drug screening and gene targeting to clinical genetics and regenerative treatments. Innovative results from stem cell research of the past decade are pointing the way toward practicable treatments for retinitis pigmentosa, age related macular degeneration, and Stargardt disease.
196p cotieubac1004 15-03-2024 2 0 Download
-
Part 1 book "Medical-Surgical nursing" includes contents: Principles of nursing assessment; principles of drug administration; principles of intravenous therapy; principles of nutritional care; principles of infection prevention and control; principles of acute care for older people; principles of end of life care; principles of perioperative nursing; principles of high dependency nursing, principles of emergency nursing.
177p muasambanhan09 16-03-2024 0 0 Download
-
Part 1 book "Drug delivery - Engineering principles for drug therapy" includes content: Introduction, drug administration and drug effectiveness, diffusion and drug dispersion, diffusion in biological systems, drug permeation through biological barriers, drug transport by fluid motion, pharmacokinetics of drug distribution.
209p muasambanhan09 12-03-2024 1 0 Download
-
Part 2 book "Drug delivery - Engineering principles for drug therapy" includes content: Drug modification, controlled drug delivery systems, case studies in drug delivery, postscript.
176p muasambanhan09 12-03-2024 1 0 Download