Genetic data

Bài giảng Khai phá dữ liệu (Data mining): Genetic algorithm, chương này trình bày những nội dung về: introduction to genetic algorithms (GA); classes of search techniques; nature to computer mapping; GA operators and parameters; example and homework;... Mời các bạn cùng tham khảo chi tiết nội dung bài giảng!

70p diepkhinhchau 18-09-2023 12 5   Download

The research project deals with two different types of data for two separate analysis. The first analysis deals with normalised RNA-seq breast cancer data where machine learning techniques are used to classify and identify the biomarker of cancer. Second analysis deals with raw DNA methylated leukemia samples to determine the mutations.

102p runthenight04 02-02-2023 8 4   Download

The research has designed a novel active truck seat suspension system for a further study of active vibration control. A 5-degree-of-freedom driver and seating suspension system model for active vibration control has been developed. A novel fast system parameter identification method from vibration measurement data has been proposed for the seat-occupant system based on the multi-objective Genetic Algorithm optimization (GA).

206p runthenight04 02-02-2023 12 5   Download

According to the ASEAN Consumer Survey conducted by HKTDC Research, ASEAN consumers, including those in Thailand, are willing to spend more on better quality products and have a strong sense of personal style. For international brands, Thailand is a key market among the developing Asian countries, not only because of its growing demand from the emerging middle-income class, but also the country’s flourishing tourism sector. Also, Thailand is a South East Asian country with close proximity to Vietnam.

42p chophen123 02-02-2021 57 10   Download

Collecting complete data of mitochondrial genome of 6 indigenous pig breeds in Vietnam (I, Mong Cai, Muong Lay, Huong, Muong Khuong and Ha Lang pigs) and deposited on the Genebank; determine the composition, structure of mitochondrial genome, compare the difference in sequence, identify specific genetic characteristics of the six indigenous pig breeds, thereby contributing to the database to identification and conservation.

27p capheviahe26 25-01-2021 15 4   Download

Cycads occur in lowland forests and are threatened by their degradation, fragmentation and over-exploitation. Our results indicate that cycad population sizes were very small (less 100 individuals) with high propagules. These increased mating between closely related individuals growing in clumps. The allozyme data show although all studied cycads maintained high levels of genetic diversity, an average of 0.556 (0.491 in C. hoabinhensis to 0.598 in C. chevalieri ), the degree of inbreeding was high.

10p 12120609 01-06-2020 19 3   Download

This paper proposed a hybrid GA rule based categorization method, named genetic algorithm rule based categorization (GARC), to enhance the accuracy of categorization rules and to produce accurate classifier for text mining.

14p tohitohi 22-05-2020 15 1   Download

(BQ) This paper reports an intelligent approach for process modeling and optimization of electric discharge machining (EDM). Physics based process modeling using finite element method (FEM) has been integrated with the soft computing techniques like artificial neural networks (ANN) and genetic algorithm (GA) to improve prediction accuracy of the model with less dependency on the experimental data.

13p xuanphuongdhts 27-03-2017 57 2   Download

The human b-globin gene locus is the subject of intense study, and over the past two decades a wealth of information has accumulated on how tissue-specific and stage-specific expression of its genes is achieved. The data are extensive and it would be difficult, if not impossible, to formulate a comprehensive model integrating every aspect of what is currently known. In this review, we introduce the fundamental characteristics of globin locus regulation as well as questions on which much of the current research is predicated.

11p system191 01-06-2013 50 4   Download

The design of b-glycosidases with planed substrate specificity for biotechnological application has received little attention. This is mostly a consequence of the lack of data on the molecular basis of the b-glycosidase specificity, namely data on the energy of the noncovalent interactions in the enzymetransition state complex. In an attempt to fill this gap, sitedirected mutagenesis and enzyme steady-state kinetic experiments with different substrates were conducted, using as model a digestive b-glycosidase (glycoside hydrolase family 1) from Spodoptera frugiperda (Lepidoptera) (Sfbgly50).

10p system191 01-06-2013 44 4   Download

The case of homologous monomeric c-type and oligomeric b-type crystallins has been described and analyzed in evolutionary terms. Data and hypotheses from molecular genetics and structural investigations converge and suggest a novel three-phase model for the evolutionary history of crystallin-type proteins. In the divergent cascades of monomeric and oligomeric crystallins, a pivotal role was played by alterations in the gene segments encoding the C-terminal extensions and the intermotif or interdomain linker peptides.

9p system191 01-06-2013 42 4   Download

Murine double minute 2 (MDM2) protein exhibits many diverse biochemi-cal functions on the tumour suppressor protein p53, including transcrip-tional suppression and E3 ubiquitin ligase activity. However, more recent data have shown that MDM2 can exhibit ATP-dependent molecular chap-erone activity and directly mediate folding of the p53 tetramer. Analysing the ATP-dependent function of MDM2 will provide novel insights into the evolution and function of the protein.

12p research12 29-04-2013 61 4   Download

This studywas designed to yield data on the supramolecular organization of the phycobilisome apparatus from Synechocystis, and the possible effects of environmental stress on this arrangement. Phycobilisomes were dissociated ina low ionic strength solutionandaquantitative estimation of the protein components present in each subcomplex was obtained using liquid chromatography coupled on-line with a mass spectrometer equipped with an electrospray ion source (ESI-MS).

9p research12 29-04-2013 50 3   Download

Pisum sativump16 is a protein present in the chromatin of ungerminated embryonic axes. The purification of p16 and the isolationof a cDNAclone ofpsp54, the gene encoding its precursor have been recently reported [Castillo, J., Rodrigo, M. I.,Ma´rquez, J. A., Zu´n˜iga, AandFranco, L. (2000)Eur. J.Biochem.267, 2156–2165]. In thepresentpaper,wepresent data showing that p16 is a nuclear protein.

8p research12 23-04-2013 38 2   Download

Fourier transform infrared spectroscopy was performed on human leukemic daunorubicin-sensitiveK562 cells and their multiresistant counterpart derived by selection. Statistical analysis, including variable reduction and linear discrimi-nant analysis was performed on sensitive and multiresistant cells spectra in order to establish a diagnostic tool for multiresistant pattern. For each of the twomethods of data reduction tested [genetic algorithm or principal component analysis (PCA)] discriminationbetween the twocell lineswas found to be possible....

6p research12 23-04-2013 43 2   Download

Trihaem cytochromec3 (also known as cytochrome c551.5 and cytochromec7 ) is isolated fromthe periplasmic space of Desulfuromonas acetoxidans, a sulfur-reducing bacterium. Thermodynamic and kinetic data for the trihaem cyto-chromec3are presented and discussed in the context of the possible physiological implications of its functional proper-ties with respect to the natural habitat of D. acetoxidans, namelyas a symbiontwithgreensulfurbacteriaworkingas a mini-sulfuretum.

9p tumor12 22-04-2013 36 4   Download

The multisubstrate deoxyribonucleoside kinase ofDroso-phila melanogaster (Dm-dNK) is sequence-related to three human deoxyribonucleoside kinases and to herpes simplex virus type-1 thymidine kinase. Dm-dNK phos-phorylates both purine and pyrimidine deoxyribonucleo-sides and nucleoside analogues although it has a preference for pyrimidine nucleosides. We performed site-directed mutagenesis on residues that, based on structural data, are involved in substrate recognition.

6p fptmusic 16-04-2013 37 3   Download

The Ca 2+ -induced transition in the troponin complex (Tn) regulates vertebrate striated muscle contraction. Tn was reconstituted with recombinant forms of troponin I (TnI) containing a single intrinsic 5-hydroxytryptophan (5HW). Fluorescence analysis of these mutants of TnI demonstrate that the regions in TnI that respond to Ca 2+ binding to the regulatoryN-domain of TnC are the inhibitoryregion (residues 96–116) and a neighboring region that includes position 121.

8p fptmusic 16-04-2013 40 4   Download

With the amount of genetic information available, a lot of attention has focused on systems biology, in particular biomolecular interactions. Con-sidering the huge number of such interactions, and their often weak and transient nature, conventional experimental methods such as X-ray crystal-lography and NMR spectroscopy are not sufficient to gain structural insight into these. A wealth of biochemical and⁄or biophysical data can, however, readily be obtained for biomolecular complexes.

20p awards 05-04-2013 49 3   Download

Experimental autoimmune encephalomyelitis can be induced in susceptible animals by immunodominant deter-minants of myelin basic protein (MBP). To characterize the molecular features of antigenic sites important for designing experimental autoimmune encephalomyelitis suppressing molecules, we report structural studies, based on NMR experimental data in conjunction with molecular dynamic simulations, of the potent linear dodecapeptide epitope of guinea pig MBP, Gln74-Lys75-Ser76-Gln77-Arg78-Ser79-Gln80-Asp81-Glu82-Asn83-Pro84-Val85 [MBP(74–85)], and its antagonist analogue Ala81MBP(74–85)....

15p awards 05-04-2013 54 3   Download