Medical therapy

Recurrent ischemic stroke due to damage to the middle cerebral artery causes deterioration of neurological function and increases the rate of disability, death, and treatment costs many times compared to the first ischemic stroke. Assessing risk factors plays an extremely important role in preventing recurrent ischemic stroke. We have discuss some risk factors for recurrent ischemic stroke caused by middle cerebral artery damage.

10p viormkorn 27-09-2024 4 2   Download

Schizophrenia is a chronic and severe mental disorder. Treatment by antipsychotic medication is one of the main therapies to control the symptoms. Medication non/poor adherence is a one of the key factors leading to relapse and declined social and occupational function in patients. This study aimed to identify the prevalence of medication non/poor adherence and its related psychosocial and clinical factors among schizophrenic patients.

8p vioraclene 31-03-2024 3 2   Download

To investigate clinical, paraclinical and 18F-FDGPET/CTimaging characteristics of postsurgical differentiated thyroid cancerpatients post RAI therapy with high serum thyroglobulin and negative 131I whole body scan. To determine the diagnostic values of 18 F-FDG-PET/CT in postsurgical differentiated thyroid cancer patients post RAI therapy with high serum thyroglobulin and negative 131 I whole body scan.

27p kequaidan12 03-06-2021 37 4   Download

To investigate clinical, paraclinical and 18F-FDGPET/CTimaging characteristics of postsurgical differentiated thyroid cancerpatients post RAI therapy with high serum thyroglobulin and negative 131I whole body scan. To determine the diagnostic values of 18 F-FDG-PET/CT in postsurgical differentiated thyroid cancer patients post RAI therapy with high serum thyroglobulin and negative 131 I whole body scan.

27p kequaidan7 01-09-2020 36 3   Download

Investigation of clinical changes, paraclinincal and some immune modifications in patients with lupus nephritis after induction therapy was indicated Mycophenolate mofetil. Investigation of clinical changes, paraclinincal and some immune modifications in patients with lupus nephritis after induction therapy was indicated Mycophenolate mofetil.

30p trinhthamhodang7 31-08-2020 25 3   Download

The new conclusions of this study: Efficacy of intra-aortic balloon pump counterpulsation (IABP) in hemodynamic support to patients with cardiogenic shock after myocardial infarction. Remarks on the efficacy of treatment and complication of intra-aortic balloon pump counterpulsation (IABP) in the treatment of cardiogenic shock after myocardial infarction

27p slimzslimz 21-12-2019 48 7   Download

The results show that the medical staff effective dose is highly dependent on the position of the medical staff. The results also show that the maximum medical staff effective dose in an emergency situation in the presence of a patient is ~25.5 mSv/s.

8p minhxaminhyeu4 26-06-2019 23 0   Download

At the end of this presentation, the participant should be able to: Cite 3 opportunistic infections where ARV therapy is part of the treatment Cite 5 opportunistic infections where ARV initiation may lead to IRS Give the appropriate management for a newly diagnosed PLWHA on TB therapy who has a CD4 count

40p motorola_12 01-06-2013 57 2   Download

Mucopolysaccharidosis type I (MPS I) results from a deficiency in the enzyme a-L-iduronidase (IDUA), and is characterized by skeletal abnormalities, hepatosplenomegaly and neurological dysfunction. In this study, we used a late generation lentiviral vector to evaluate the utility of this vector system for the transfer and expression of the human IDUA cDNA in MPS I fibroblasts. We observed that the level of enzyme expression in transduced cells was 1.5-fold the level found in normal cells; the expression persisted for at least two months....

8p system191 01-06-2013 31 5   Download

There are at least three well-defined signalling cascades engaged directly in the physiological regulation of cardiac circulatory function: theb1-adrenoceptors that control the cardiac contractile apparatus,the renin-angiotensin-aldo-sterone system involved in regulating bloodpressure and the natriuretic peptides contributing at least to the factors determining circulating volume.

18p research12 29-04-2013 39 3   Download

UMP-CMP kinase catalyses an important step in the phosphorylationofUTP, CTPanddCTP. It is also involved in the necessary phosphorylation by cellular kinases of nucleoside analogs used in antiviral therapies. The reactivity of human UMP-CMP kinase towards natural substrates and nucleotide analogs was reexamined. The expression of the recombinant enzyme and conditions for stability of the enzyme were improved. Substrate inhibition was observed for UMP and CMP at concentrations higher than 0.2 mM, but not for dCMP.

7p fptmusic 16-04-2013 36 3   Download

RNAreprogramming represents anewconcept incorrecting genetic defects at theRNA level.However, for the technique to be useful for therapy, the level of reprogrammingmust be appropriate. To improve the efficiency of group I ribozyme-mediated RNA reprogramming, when using theTetrahy-menaribozyme, regions complementary to the target RNA have previously been extended in length and accessible sites in the targetRNAs have been identified.

0p awards 05-04-2013 35 3   Download

The spontaneous acquisition of resistance to a variety of unrelated cytotoxic compounds has important implications in medical treatment of infectious diseases and anticancer therapy. In the yeast Saccharomyces cerevisiaethis pheno-menon is caused by overexpression of membrane efflux pumps and is called pleiotropic drug resistance. We have found that allelic forms of the genes for the transcription activators Pdr1p and Pdr3p, designated PDR1-12and PDR3-33,respectively, mediate resistance to diazaborine....

8p dell39 03-04-2013 38 3   Download

Anti-poxvirus therapies are currently limited to cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine], but drug-resistant strains have already been characterized. In the aim of finding a new target, the thymidy-late (TMP) kinase from vaccinia virus, the prototype of Orthopoxvirus, has been overexpressed inEscherichia coliafter cloning the gene (A48R).

12p dell39 27-03-2013 39 4   Download

Both microtubule destabilizer and stabilizer agents are important molecules in anticancer therapy. In particular, paclitaxel has been demonstrated to be effective for the treatment of ovarian, breast, and nonsmall cell lung carci-nomas. It has been shown that emergence of resistance against this agent correlates with an increase in the relative abundance of tubulin isoform bIII and that the more recently discovered IDN5390 can be effectively used once resistance has emerged.

10p inspiron33 25-03-2013 42 4   Download

Decaprenyl-phospho-arabinose (b-d-arabinofuranosyl-1-O-monophospho-decaprenol), the only known donor of d-arabinose in bacteria, and its precursor, decaprenyl-phospho-ribose (b-d-ribofuranosyl-1-O-monophospho-decaprenol), were first described in 1992.

21p media19 06-03-2013 50 4   Download

The Drosophila melanogaster multisubstrate deoxyribonucleoside kinase (dNK; EC 2.7.1.145) has a high turnover rate and a wide substrate range that makes it a very good candidate for gene therapy. This concept is based on introducing a suicide gene into malignant cells in order to activate a prodrug that eventually may kill the cell.

10p media19 06-03-2013 36 4   Download

Regulated gene expression may substantially enhance gene therapy. Corre-lated with structural differences between insect ecdysteroids and mamma-lian steroids, the ecdysteroids appear to have a benign pharmacology without adversely interfering with mammalian signaling systems. Conse-quently, the ecdysone receptor-based gene switches are attractive for appli-cation in medicine.

21p media19 04-03-2013 36 5   Download

Protein misfolding is recognized as an important pathophysiological cause of protein deficiency in many genetic disorders. Inherited mutations can disrupt native protein folding, thereby producing proteins with misfolded conformations.

10p media19 04-03-2013 23 2   Download

Enzyme enhancement therapy is an emerging therapeutic approach that has the potential to treat many genetic diseases. Candidate diseases are those associated with a mutant protein that has difficulty folding and⁄or assembling into active oligomers in the endoplasmic reticulum.

11p media19 04-03-2013 38 2   Download