Non-canonical
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Ebook "TNF receptor associated factors (TRAFs)" is the only literature that is entirely devoted to TRAFs. Almost every aspect of TRAF signaling is covered, including the different TRAF family members, their distinct biological functions, the TRAF structures, their modes of receptor recognition, the signaling mechanisms, and the roles of TRAFs in normal cellular functions and in viral infection.
222p ladongphongthanh1008 22-04-2024 1 1 Download
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Genomic imprinting is an epigenetic phenomenon that allows a subset of genes to be expressed mono-allelically based on the parent of origin and is typically regulated by differential DNA methylation inherited from gametes.
17p vielonmusk 30-01-2022 7 1 Download
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To discover driver fusions beyond canonical exon-to-exon chimeric transcripts, we develop CICERO, a local assembly-based algorithm that integrates RNA-seq read support with extensive annotation for candidate ranking. CICERO outperforms commonly used methods, achieving a 95% detection rate for 184 independently validated driver fusions including internal tandem duplications and other noncanonical events in 170 pediatric cancer transcriptomes.
18p viarchimedes 26-01-2022 11 0 Download
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G-Quadruplexes, a class of noncanonical but highly stable nucleic acid structures, have the potential to be part of the regulatory mechanism of cells. They can form in the genome where the double-stranded helix is unwound to facilitate formation of a G-quadruplex. The biological significance of these structures is yet to be understood entirely. This work presents a novel approach and investigates common characteristics in the distribution of G-quadruplexes relative to genes in plants through analysis of genomes and gene expressions.
16p tudichquannguyet 29-11-2021 6 1 Download
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The Wnt receptors ROR1 and ROR2 are generating increased interest as cancer therapeutic targets but remain understudied in pancreatic ductal adenocarcinoma (PDAC). Compared to canonical Wnt/ β-catenin signalling, the role of noncanonical Wnt signalling in PDAC remains largely unknown.
11p vimahuateng 26-11-2021 7 1 Download
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It is generally thought that most canonical or non-canonical splicing events involving U2- and U12 spliceosomes occur within nuclear pre-mRNAs. However, the question of whether at least some U12-type splicing occurs in the cytoplasm is still unclear. In recent years next-generation sequencing technologies have revolutionized the field.
12p viflorida2711 30-10-2020 8 2 Download
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Both Wnt5a overexpression and macrophage infiltration have been implicated in inflammation and cancer. The aim of this study is to reveal the involvement of Wnt5a in macrophage recruitment in gastric cancer.
9p virose2711 22-09-2020 8 2 Download
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Dynamic visualizations: On ‘non-canonical’ keyboard-input and terminal escape-sequences for visualization effects includes Our course’s theme, Two ‘dynamic visualizations’, Some application tools, The ‘tty’ interface, The ‘c_lflag’ field.
23p maiyeumaiyeu18 01-11-2016 28 2 Download
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Natural language systems based on Categorial Unification Grammar (CUG) have mainly employed bottomup parsing algorithms for processing. Conventional prediction techniques to improve the efficiency of the • parsing process, appear to fall short when parsing CUG. Nevertheless, prediction seems necessary when parsing grammars with highly ambiguous lexicons or with noncanonical categorial rules. In this paper we present a lexicalist prediction technique for CUG and show thai this may lead to considerable gains in efficiency for both bottom-up and top-down parsing. ...
6p buncha_1 08-05-2013 51 1 Download
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Gomesin is the first peptide isolated from spider exhibiting antimicrobial activities. This highly cationic peptide is composed of 18 amino-acid residues including four cysteines forming two disulfide linkages. The solution structure of gomesin has been determined using proton two-dimensional NMR (2D-NMR) and restrained molecular dynamics calculations. The global fold of gomesin consists in a wellresolved two-stranded antiparallel b sheet connected by a noncanonical b turn.
9p research12 01-06-2013 30 2 Download
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Steedman (1985, 1987) and others have proposed that Categorial Grammar, a theory of syntax in which grammatical categories are viewed as functions, be augmented with operators such as functional composition and type raising in order to analyze • noncanonical" syntactic constructions such as wh- extraction and node raising. A consequence of these augmentations is an explosion of semantically equivalent derivations admitted by the grammar. The present work proposes a method for circumventing this spurious ambiguity problem.
8p bungio_1 03-05-2013 46 1 Download
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Multimolecular complexes involving the eukaryotic elongation factor 1A (eEF1A) have been suggested to play an important role in the channeling (vectorial transfer) of tRNAduring protein synthesis [Negrutskii, B.S.&El’skaya, A.V. (1998)Prog. Nucleic Acids Res. Mol. Biol.60,47–78]. Recently we have demonstrated that besides performing its canonical function of forming a ternary complex with GTP and aminoacyl-tRNA, the mammalian eEF1A can produce a noncanonical ternary complex with GDP and uncharged tRNA [Petrushenko, Z.M., Negrutskii, B.S.,...
8p research12 29-04-2013 38 2 Download
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The transcription factorNF-jB is activated in cellular stress responses. This requires rapid regulation of its function, which is accomplished, in part, by various modes of phos-phorylation. Even though diverseDNAbinding subunits of NF-jB proteins may transactivate fromdistinct recognition sequences, the differential regulation of transcription from the large number of NF-jB responsive sites in various gene promoters andenhancershasbeen incompletelyunderstood.
12p fptmusic 16-04-2013 49 1 Download
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The introduction of noncanonical amino acids and bio-physical probes into peptides and proteins, and total or segmental isotopic labelling has the potential to greatly aid thedeterminationofproteinstructure, functionandprotein– protein interactions.To obtain a peptide as large as possible by solid-phase peptide synthesis, native chemical ligation was introduced to enable synthesis of proteins of up to 120 amino acids in length.
15p dell39 03-04-2013 40 3 Download
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Formylglycine-generating enzyme (FGE) catalyzes in newly synthesized sul-fatases the oxidation of a specific cysteine residue to formylglycine, which is the catalytic residue required for sulfate ester hydrolysis. This post-trans-lational modification occurs in the endoplasmic reticulum (ER), and is an essential step in the biogenesis of this enzyme family.
13p media19 06-03-2013 45 1 Download
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Many protein substrates of caspases are cleaved at noncanonical sites in comparison to the recognition motifs reported for the three caspase sub-groups. To provide insight into the specificity and aid in the design of drugs to control cell death, crystal structures of caspase-7 were determined in complexes with six peptide analogs (Ac-DMQD-Cho, Ac-DQMD-Cho, Ac-DNLD-Cho, Ac-IEPD-Cho, Ac-ESMD-Cho, Ac-WEHD-Cho) that span the major recognition motifs of the three subgroups.
14p media19 04-03-2013 37 3 Download
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Plastid envelope DNA-binding protein (PEND) is a DNA-binding protein with a chloroplast basic region-zipper domain at its N-terminus and a transmembrane domain at its C-terminus. The localization of PEND to the inner envelope membrane was demonstrated in a targeting experiment using isolated membranes and green fluorescent protein-tagged fusion pro-teins.
11p vinaphone15 27-02-2013 31 1 Download
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The multifunctional tissue transglutaminase 2 (TG2) has a four-domain structure with several Ca 2+ -regulated biochemical activities, including transglutamylation and GTP hydrolysis. The structure of the Ca 2+ -binding form of the human enzyme is not known, and its Ca 2+ -binding sites have not been fully characterized.
14p vinaphone15 25-02-2013 28 1 Download
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Nucleotide hydrolases are known to hydrolyze not only noncanonical dNTPs to reduce the risk of mutation, but also canonical dNTPs to main-tain the dNTP concentrations in the cell. dGTP triphosphohydrolase from Escherichia coliis known as an enzyme that hydrolyzes dGTP.
11p viettel02 22-02-2013 31 2 Download