Phenolic compounds

Avocado peel has been considered as a potential source of natural antioxidants in which phenolics are among the most important compounds. Therefore, this study aims to optimize the extraction process of phenolics using response surface methodology and evaluate the corresponding antioxidant activity.

11p viuchiha 03-01-2025 0 0   Download

Master's thesis of Science "Investigation into the modulation of circadian clock proteins by dietary compounds and small molecules" is structured as follows: Chapter 1 Introduction; Chapter 2 Identification of novel bioactive compounds from Olea europaea by evaluation of chemical compounds in the OliveNetTM library: in silico bioactivity and molecular modelling, and in vitro validation of hERG activity; Chapter 3 Modulation of circadian core clock proteins by dietary compounds; Chapter 4 Molecular mechanisms of action of selected olive phenolics against epigenetic modifiers and the structur...

235p runthenight04 02-02-2023 5 3   Download

The study revealed that the tested compounds are moderate UVB absorbers, but could be used to augment the effect of other photoprotective agents. Their SPF values were in the range from 3.63 to 4.26 for salicylates 3a-d and from 3.03 to 3.51 for vanillates.

10p tocectocec 25-05-2020 11 3   Download

Sugar conjugation is a major pathway for the inactivation and excretion of both endogenous and exogenous compounds. We report here the molecular cloning and functional characterization of a phenol UDP-glucosyltransferase (UGT) from the silkworm, Bombyx mori, which was named BmUGT1. The complete cDNA clone is 1.6 kb, and the gene is expressed in several tissues of fifth-instar larvae, including fat body, midgut, integument, testis, silk gland and haemocytes. The predicted protein comprises 520 amino acids and has  30% overall amino-acid identity with other members of the UGT family.

7p research12 01-06-2013 39 4   Download

To investigate how solubility and steric issues affect the laccase-catalysedoxidationof phenols, a series of oligomeric polyphenol compounds, having increasing size and decreasing solubility in water, was incubated with laccase. The extent of substrate conversion, and the nature of the products formed in buffered aqueous solutions, were com-pared to those obtained in the presence of an organic cosolvent, and also in the presence of twomediating species, i.e. N-hydroxyphthalimide (HPI) and 2,2,6,6-tetramethyl-piperidin-1-yloxy (TEMPO). ...

6p tumor12 22-04-2013 42 2   Download

The sulfonephthalein indicator, phenol red, exhibits an unusually slow rate of oxidation by laccase fromPolipo-rus pinsitus, in spite of the fact that it is a phenol and therefore a natural substrate for this phenoloxidase enzyme. Nevertheless, after prolonged exposure to laccase (24 h) phenol red is oxidized by more than 90%.

7p tumor12 20-04-2013 40 2   Download

CYP73 enzymes are highly conserved cytochromes P450 in plant species that catalyse the regiospecific 4-hydroxylation ofcinnamicacid to formprecursorsofligninandmanyother phenolic compounds. A CYP73A1 homology model based on P450 experimentally solved structures was used to iden-tify active site residues likely togovern substrate binding and regio-specific catalysis. The functional significance of these residues was assessed using site-directedmutagenesis.

12p tumor12 20-04-2013 40 3   Download

Plant flavonoids are polyphenolic compounds, commonly found in vegeta-bles, fruits and many food sources that form a significant portion of our diet. These compounds have been shown to interact with several ATP-bind-ing cassette transporters that are linked with anticancer and antiviral drug resistance and, as such, may be beneficial in modulating drug resistance. This study investigates the interactions of six common polyphenols; querce-tin, silymarin, resveratrol, naringenin, daidzein and hesperetin with the multidrug-resistance-associated proteins, MRP1, MRP4 and MRP5. ...

16p fptmusic 12-04-2013 40 2   Download

Human UDP-glucuronosyltransferase 1A (UGT1A) isoforms are endoplas-mic reticulum (ER)-resident type I membrane proteins responsible for the detoxification of a broad range of toxic phenolic compounds. These pro-teins contain a C-terminal stop transfer sequence with a transmembrane domain (TMD), which anchors the protein into the membrane, followed by a short cytosolic tail (CT).

9p awards 05-04-2013 35 4   Download

Peroxidases perform the nitration of tyrosine and tyrosyl residues in proteins, in the presence of nitrite and hydrogen peroxide. The nitrating species is still unknown but it is usually assumed to be nitrogen dioxide. In the present investigation, the nitration of phenolic compounds derived from tyrosine by lactoperoxidase and horseradish peroxi-dasewas studied, with the aimof elucidating themechanism of the reaction.

12p dell39 03-04-2013 54 4   Download

Polyphenol oxidase (PPO) catalyzes the oxidation ofo-diphenols to their respective quinones. The quinones autopolymerize to form dark pigments, an undesired effect. PPO is therefore the target for the development of antibrowning and antimelanization agents. A series of phenolic compounds experimentally evaluated for their binding affinity and inhibition constants were computationally docked to the active site of catechol oxidase.

11p media19 04-03-2013 33 5   Download

Phthiocerol and phthiodiolone dimycocerosates (DIMs) and phenolic gly-colipids (PGLs) are complex lipids located at the cell surface ofMycobacte-rium tuberculosis that play a key role in the pathogenicity of tuberculosis. Most of the genes involved in the biosynthesis of these compounds are clustered on a region of the M. tuberculosischromosome, the so-called DIM + PGL locus.

11p mobifone23 21-01-2013 48 4   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Phenolic compounds in ectomycorrhizal interaction of lignin modified silver birch

15p panasonic06 25-12-2011 47 5   Download