Regulator of G protein signaling
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Ebook "RAMPs (Advances in experimental medicine and biology, Volume 744)" provides a general introduction to RAMPs including its discovery. The second chapter (by Poyner and colleagues) and the third chapter (by Bomberger and colleagues) are intended to provide in depth discussion on how the different RAMP isoforms can regulate various aspects of receptor signaling especially stimulated with calcitonin gene related peptide (CGRP) and adrenomedullin. In addition, in the third chapter, Bomberger et al discuss the differences in RAMP2 and -3 with regard to their role in receptor trafficking.
126p cotieubac1004 15-03-2024 2 0 Download
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Preeclampsia is a common and heterogeneous vascular syndrome of pregnancy. Its genetic risk profile is yet unknown and may vary between individuals and populations. The rs4606 3′ UTR polymorphism of the Regulator of G-protein signaling 2 gene (RGS2) in the mother has been implicated in preeclampsia as well as in the development of chronic hypertension after preeclampsia.
7p vinarcissa 21-03-2023 1 1 Download
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G-protein coupled receptors (GPCRs) are ancient, ubiquitous, constitute the largest family of transducing cell surface proteins, and are integral to cell communication via an array of ligands/neuropeptides.
20p vigiselle2711 30-08-2021 10 1 Download
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Cancer stem cells (CSCs) are believed to promote the malignant transformation of breast cancer via multiple signaling pathways, including the Wnt/β-catenin pathway. Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) has been identified as a CSC-associated Wnt-regulated target gene, but its clinical significance in the context of breast cancer remains elusive.
8p vibaku2711 22-07-2020 9 1 Download
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Regulators of G protein signaling (RGS) proteins modulate G protein-coupled receptor (GPCR) signaling networks by terminating signals produced by active Gα subunits. RGS17, a member of the RZ subfamily of RGS proteins, is typically only expressed in appreciable amounts in the human central nervous system, but previous works have shown that RGS17 expression is selectively upregulated in a number of malignancies, including lung, breast, prostate, and hepatocellular carcinoma.
10p caothientrangnguyen 09-05-2020 10 0 Download
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Regulator of G-protein signaling (RGS) proteins were originally identified as negative regulators of G-protein-coupled receptor (GPCR) signaling via their GTPase-accelerating protein (GAP) activity. All RGS proteins contain evolutionarily conserved RGS domain; however, they differ in their size and regulatory domains. RGS1 and RGS10 are smaller than other RGS proteins, and their functions involve various inflammatory responses including autoimmune responses in both the periphery and the central nervous system (CNS). Neuroinflammation is the chronic inflammatory response in the CNS.
5p caothientrangnguyen 09-05-2020 22 1 Download
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Regulator of G protein signaling (RGS) proteins are gatekeepers regulating the cellular responses induced by G protein-coupled receptor (GPCR)-mediated activation of heterotrimeric G proteins. Specifically, RGS proteins determine the magnitude and duration of GPCR signaling by acting as a GTPase-activating protein for Gα subunits, an activity facilitated by their semiconserved RGS domain. The R7 subfamily of RGS proteins is distinguished by two unique domains, DEP/DHEX and GGL, which mediate membrane targeting and stability of these proteins.
13p caothientrangnguyen 09-05-2020 20 0 Download
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The heterotrimeric G protein complex, consisting of Gα, Gβ, and Gγ subunits, are conserved signal transduction mechanism in eukaryotes. Recent molecular researches had demonstrated that G protein signaling participates in the regulation of yield related traits.
13p viharuno2711 21-04-2020 6 1 Download
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Regulator of G protein signaling (RGS) proteins suppress G protein coupled receptor signaling by catalyzing the hydrolysis of Gα-bound guanine nucleotide triphosphate. Transgenic mice in which RGS-mediated regulation of Gαi2 is lost (RGS insensitive Gαi2 G184S) exhibit beneficial (protection against ischemic injury) and detrimental (enhanced fibrosis) cardiac phenotypes.
13p vienzym2711 03-04-2020 23 2 Download
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Dilated cardiomyopathy (DCM) is the most common form of non-ischemic cardiomyopathy. It is characterized by ventricular chamber dilation, and myocyte hypertrophy. Human tumorous imaginal disc 1 (Tid1), a chaperone protein and response to regulate number of signaling molecules in the mitochondria or cytosol.
10p vihasaki2711 12-11-2019 9 0 Download
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We have previously reported the Ras-dependent activation of the mitogen-activated protein kinases p44 and p42, also termed extracellular signal-regulated kinases (ERK)1 and 2 (ERK1⁄2), mediated through Gs-coupled serotonin receptors transiently expressed in human embryonic kidney (HEK) 293 cells. Whereas G i- and Gq-coupled receptors have been shown to activate Ras through the guanine nucleotide exchange factor (GEF) called Ras-GRF1 (CDC25 Mm ) by binding of Ca 2+ ⁄calmodulin to its N-terminal IQ domain, ...
0p awards 06-04-2013 32 1 Download
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Regulator of G protein signaling (RGS) proteins act as GTPase-activating proteins (GAPs) for Gasubunits and negatively regulate G protein-coupled receptor signaling. Using RGS5 gene-specific RT-PCR, we have identified a novel alternative splicing variant of RGS5 mRNA in human ocular tissues. The alternative splicing of RGS5 mRNA occurred at position +44 (GenBank NM_003617), spliced out 174 bp (+44 to +218 bp) of the cod-ing region, and encoded an RGS5s protein with a 108 amino acid N-ter-minal deletion. ...
0p awards 05-04-2013 35 1 Download
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Accumulating evidence indicates that G protein signaling plays an active role in the regulation of cell survival. Our previous study demonstrated the regulatory effects of Gi⁄ o proteins in nerve growth factor-induced activa-tion of pro-survival Akt kinase. In the present study we explored the role of various members of the Gs,Gq⁄ 11 and G12⁄ 13 subfamilies in the regula-tion of Akt in cultured mammalian cells.
11p inspiron33 26-03-2013 43 3 Download
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Heterotrimeric G proteins participate in signal transduction by transferring signals from cell surface receptors to intracellular effector molecules. G proteins also interact with microtubules and participate in microtubule-dependent centrosome⁄chromosome movement during cell division, as well as neuronal differentiation.
10p inspiron33 23-03-2013 33 3 Download
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Signal transduction mediated by heterotrimeric G proteins regulates a wide variety of physiological functions. We are interested in the manipulation of G-protein-mediating signal transduction using G-protein-coupled receptors, which are derived from evolutionarily distant organisms and recognize unique ligands.
9p inspiron33 23-03-2013 44 3 Download
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The voltage-gated potassium channel Kv4.3 was coexpressed with itsb-sub-unit Kv channel-interacting protein 2 and the angiotensin type 1 receptor in HEK-293 cells. Proteomic analysis of proteins coimmunoprecipitated with Kv4.3 revealed that Kv4.3 is associated with Rap guanine nucleotide exchange factors MR-GEF and EPAC-1.
10p media19 04-03-2013 34 1 Download
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The unique ability of mammals to detect and discriminate between thou-sands of different odorant molecules is governed by the diverse array of olfactory receptors expressed by olfactory sensory neurons in the nasal epithelium. Olfactory receptors consist of seven transmembrane domain G protein-coupled receptors and comprise the largest gene superfamily in the mammalian genome.
12p vinaphone15 27-02-2013 41 2 Download
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Regulators of G-protein signalling accelerate the GTPase activity of Ga subunits, driving G proteins in their inactive GDP-bound form. This property defines them as GTPase activating proteins.
11p vinaphone15 27-02-2013 26 1 Download
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Signaling cascades, in addition to proteins with obvious signaling-relevant activities (e.g. protein kinases or receptors), also employ dedicated ‘inactive’ proteins whose functions appear to be the organization of the former com-ponents into higher order complexes through protein–protein interactions. The core function of signaling adaptors, anchors and scaffolds is the recruitment of proteins into one macromolecular complex.
7p viettel02 19-02-2013 38 1 Download
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Adrenergic receptors (ARs) are expressed in almost all organs and tissues and regulate a large number of diverse physiological processes upon activation by epinephrine and norepinephrine. There are three families of ARs, a1, a2, and b-ARs, with distinct pharmacological properties and functions. Since the first identification of bARs more than three decades ago, research on ARs has led to the establishment of many fundamental concepts in G protein-coupled receptor (GPCR) pharmacology.
0p hotmoingay 04-01-2013 62 2 Download