Scientific computing

This article presents the modeling and the nonlinear dynamic analysis of base-isolated frame structures using linear theory (with non-classical damping matrix) and nonlinear theory (with 6-parameter Bouc-Wen bearing model). The computations are done with the aid from Julia scientific language.

8p viyoko 24-09-2024 4 1   Download

The thesis is structured as follows: In Chapter 1, the scientific literature is summarized within the scope of this study. Chapter 2 provides a comprehensive overview of the principles of the applied computational approaches in this study. Chapter 3 identifies the important residues of the LsIA/α7 nAChR complex that affect the interactions between the toxin and the membrane protein due to C-terminal carboxylation of LsIA. The effects of C-terminal modification of LsIA on interactions with α3β2 nAChR, involved in cardiovascular diseases, were also investigated in Chapter 4.

234p runthenight04 02-02-2023 11 3   Download

The thesis mainly aims to solve the following tasks: Firstly, the thesis extensively analyzes a wide range of existing approaches for the ME detection in scientific document images. Then, the thesis investigates and proposes novel methods to improve the detection accuracy of MEs. After enhancing the detection accuracy of MEs, the thesis investigates and pro poses a framework to improve the accuracy of the recognition of MEs in scientific document images.

27p closefriend09 16-11-2021 22 4   Download

The thesis mainly aims to solve the following tasks: Firstly, the thesis extensively analyzes a wide range of existing approaches for the ME detection in scientific document images. Then, the thesis investigates and proposes novel methods to improve the detection accuracy of MEs. After enhancing the detection accuracy of MEs, the thesis investigates and pro poses a framework to improve the accuracy of the recognition of MEs in scientific document images.

154p mintmintt 05-10-2021 12 3   Download

Research objectives: To study rainfall-runoff changes, to downscale rainfall and surface over time and space, and to establish scientific base for calculation of design flood for transportation structures.

28p dolphintaletale 23-04-2021 29 6   Download

This study develops unconditionally monotone finite-difference scheme of second-order of local approximation on uniform grids for the initial boundary problem value for the Gamma equation through the establishment of two-side estimates for the scheme’s solution.

8p tamynhan6 14-09-2020 17 2   Download

N-Acetylglucosamine is a major component of com-plex carbohydrates. The mammalian salvage pathway of N-acetylglucosamine recruitment from glycoconjugate deg-radation or nutritional sources starts with phosphorylation byN-acetylglucosamine kinase. In this studywe describe the identification of two active site cysteines of the sugar kinase by site-directed mutagenesis and computer-based structure prediction.

7p research12 23-04-2013 33 2   Download

A computer program has been evaluated for subsite map calculations of depolymerases. The program runs inWIN-DOWSanduses the experimentallydeterminedbond cleavage frequencies (BCFs) for determination of the number of subsites, the position of the catalytic site and for calculation of subsite binding energies. The apparent free energy values were optimized by minimization of the differences of the measured and calculated BCF data.

6p tumor12 22-04-2013 39 5   Download

Protein molecular modelling and ligand docking were employed for the design of anthraquinone galactosyl-bio-mimetic dye ligands (galactosyl-mimodyes) for the target enzyme galactose dehydrogenase (GaDH). Using appro-priate modelling methodology, a GaDH model was build based on a glucose-fructose oxidoreductase (GFO) protein template.

15p tumor12 22-04-2013 46 2   Download

Two dimensional electrophoresis has revealed a micro-heterogeneity in the recombinant human phenylalanine hydroxylase (hPAH) protomer,that is the result of sponta-neous nonenzymatic deamidations of labile asparagine (Asn) residues [Solstad,T. and Flatmark,T. (2000)Eur. J. Biochem.267,6302–6310].

10p tumor12 20-04-2013 25 1   Download

The wealth of available genomic data has spawned a corresponding interest in computational methods that can impart biological meaning and context to these experiments. Traditional computational methods have drawn rela-tionships between pairs of proteins or genes based on notions of equality or similarity between their patterns of occurrence or behavior. For exam-ple, two genes displaying similar variation in expression, over a number of experiments, may be predicted to be functionally related.

9p fptmusic 12-04-2013 41 4   Download

Due to the unavoidable nonbiological variations accompanying many experiments, it is imperative to consider a way of unravelling the functional interaction structure of a cellular network (e.g. signalling cascades or gene networks) by using the qualitative information of time-series experimental data instead of computation through the measured absolute values.

10p fptmusic 11-04-2013 49 3   Download

To achieve a structural context for the analysis of G-protein coupled recep-tor (GPCR) oligomers, molecular modeling must be used to predict the corresponding interaction interfaces. The task is complicated by the paucity of detailed structural data at atomic resolution, and the large number of possible modes in which the bundles of seven transmembrane (TM) seg-ments of the interacting GPCR monomers can be packed together into dimers and⁄or higher-order oligomers.

13p fptmusic 11-04-2013 48 3   Download

To lay the foundations for a systematic procedure that could be applied to any scientific translation, this experiment evaluates the error variances attributable to various sources inherent in a design in which discrete, randomly ordered sentences from translations are rated for intelligibility and for fidelity to the original.

12p nghetay_1 06-04-2013 72 2   Download

A system of procedures and computer programs is proposed for the semi-automatic synthesis of Russian-English translation algorithms. For the purposes of automatic formula finding, a large corpus of Russian scientific and technical text may be processed by an automatic Russian-English dictionary, the resulting word-by-word translation postedited according to a systematic procedure, and the final translation transcribed back onto magnetic tape for input to a computer.

14p nghetay_1 06-04-2013 56 3   Download

PREOCCUPATION with the problems of communication across language barriers has resulted in our time in the perfection, progressive application, or investigation of three new techniques.

0p nghetay_1 06-04-2013 80 3   Download

The transmembrane topology of presenilins is still the subject of debate despite many experimental topology studies using antibodies or gene fusions. The results from these studies are partly contradictory and conse-quently several topology models have been proposed. Studies of preseni-lin-interacting proteins have produced further contradiction, primarily regarding the location of the C-terminus.

0p awards 06-04-2013 34 3   Download

The glyoxalase pathway ofLeishmania infantumwas kinetically character-ized as a trypanothione-dependent system. Using time course analysis based on parameter fitting with a genetic algorithm, kinetic parameters were estimated for both enzymes, with trypanothione derived substrates. A Kmof 0.253 mmand aVof 0.21lmolÆmin )1 Æmg )1 for glyoxalase I, and a Kmof 0.098 mmand aVof 0.18lmolÆmin )1 Æmg )1 for glyoxalase II, were obtained.

11p awards 06-04-2013 46 2   Download

This work presents a computational analysis of the molecular characteris-tics shared by the adenylation domains from traditional nonribosomal pep-tide synthetases (NRPSs) and the group of the freestanding homologous enzymes: a-aminoadipate semialdehyde dehydrogenase, a-aminoadipate reductase and the protein Ebony. The results of systematic sequence com-parisons allow us to conclude that a specificity-conferring code, similar to that described for the NRPSs, can be recognized in such enzymes.

13p awards 05-04-2013 34 3   Download

Toovercome the difficultyof characterizing the structures of the extracellular loops (eLPs) ofGprotein-coupledreceptors (GPCRs) other than rhodopsin, we have explored a strategy to generate a three-dimensional structural model for a GPCR, the thromboxane A2 receptor. This three-dimen-sional structurewas completedby the assembly of theNMR structures of the computation-guided constrained peptides that mimicked the extracellular loops and connected to the conserved seven transmembrane domains.

11p awards 05-04-2013 39 4   Download