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  • Site Navigation được dùng để di chuyển giữa các trang trong website, quản lý tất cả các link, hiển thị các Link trong danh sách hoặc menu. Để hiểu rõ hơn về điều này mời các bạn tham khảo Bài giảng Phát triển web nâng cao - Bài 9: Site Navigation.

    pdf8p maiyeumaiyeu28 13-01-2017 55 6   Download

  • Site Navigation được dùng để: • Di chuyển giữa các trang trong website • Quản lý tất cả các link • Hiển thị các Link trong danh sách hoặc menu trên mỗi trang • Mô tả bố cục của WebSite như một hệ thống thứ bậc .Sử dụng Site Navigation • Site Map • Site Navigation: – Menu – SiteMapPath – TreeView • Site Map với Master pages

    pdf8p nobita_12 18-11-2013 62 3   Download

  • Như các bạn đã biết trong công việc của một SEOER được lập đi lập lại với 2 quá trình chủ chốt làm nền tảng đó là Onpage và Offpage, thông thường thì Onpage gần như là giống nhau và giữa site ta đang làm SEO với site đối thủ hơn thua nhau chính là ở công đoạn Offpage... Warning: Hãy bỏ ra 10 phút để đọc bạn sẽ tiết kiệm được công sức cho cả đời và có 1 kho tàng kiến thức mà lâu nay bạn vẫn còn mập mờ hoặc chưa hề biết đến. ...

    pdf9p hihinn 21-08-2013 64 9   Download

  • .10 thủ thuật sau sẽ giúp bạn thực hiện Local Seo tốt hơn. 1. Tạo Profile của bạn Rất đơn giản, bạn chỉ cần tạo profile của mình tại Google Places, Bing Local và Yahoo Local . Các thông tin tối thiểu cần có là Tên công ty, điện thoại, địa chỉ, lĩnh vực hoạt động… Tài liệu Local Seo Tiếng Việt – hướng dẫn seo Trên google maps .2. Upload hình ảnh Các local site sẽ cung cấp cho người dùng hình ảnh về công ty của bạn cũng như là hình ảnh về hàng hóa của bạn. Không cần phải là những...

    pdf8p fifinn 21-08-2013 76 6   Download

  • To search for novel regulatory regions, we examined the features of chromatin structure in the rat B29/Ig-b gene and its flanking regions by determining DNase I hypersensitive sites (DHS) in plasmacytoma-derived Y3 cells. Six Y3 cellspecific DHS were detected at )8.6, promoter, +0.7, +4.4, +6.0, and +8.7 kb. The DHS at +4.4, +6.0, and +8.7 kb were present in the intergenic region between B29/Ig-b and growth hormone (GH) genes and were mapped inside conserved sequences in rat and humans.

    pdf10p research12 01-06-2013 29 4   Download

  • Integrin a2b1 is the major receptor for collagens in human tissues, being involved in cell adhesion and the control of collagen and collagenase gene expression. The collagen binding site of a2b1 has been localized to the a2 von Willebrand Factor type A (VWFA) domain (A-domain or I-domain) and the residues responsible for the interaction with collagen have been mapped. We report a study of a2 VWFA domain in which residue E318, which lies outside the collagen binding site, is mutated to tryptophan, showing that this is a gain-of-function mutation. ...

    pdf9p research12 01-06-2013 35 5   Download

  • The cystic ®brosis transmembrane conductance regulator (CFTR) gene shows a complex pattern of expression, with temporal and spatial regulation that is not accounted for by elements in the promoter. One approach to identifying the regulatory elements forCFTRis the mapping of DNase I hypersensitive sites (DHS) within the locus. We previously identi®ed at least 12 clusters of DHS across theCFTRgene andhere further evaluateDHS in introns 2, 3, 10, 16, 17a, 18, 20 and 21 to assess their functional importance in regulation ofCFTRgene expression. ...

    pdf7p research12 23-04-2013 30 2   Download

  • A computer program has been evaluated for subsite map calculations of depolymerases. The program runs inWIN-DOWSanduses the experimentallydeterminedbond cleavage frequencies (BCFs) for determination of the number of subsites, the position of the catalytic site and for calculation of subsite binding energies. The apparent free energy values were optimized by minimization of the differences of the measured and calculated BCF data.

    pdf6p tumor12 22-04-2013 39 5   Download

  • The thyrotropin receptor (TSHR) undergoes a cleavage at the cell membrane, leading to a heterodimer, comprising an aextracellular and a b-transmembrane and intracellular subunits, held togetherbydisulfidebonds.Moreover, part of the a-subunit of the receptor is shed from thyroid and transfected L cells.To understand the role of cleavage and shedding, we constructed deletion mutants starting, respectively, at the most N-terminal (S314), and C-terminal (L378) cleavage sites previously mapped, corresponding to free b1orb2-subunits without further modification of receptor structure....

    pdf12p tumor12 20-04-2013 37 2   Download

  • The mitogen activated protein (MAP) kinase module: (Raf fiMEKfiERKs) is central to the control of cell growth, cell differentiation and cell survival. The fidelity of signalling and the spatio-temporal activation are key deter-minants in generating precise biological responses. The fidelity is ensured by scaffold proteins – protein kinase insulators – andby specific docking sites. The duration and the intensity of the response are in part controlled by the compartmentalization of the signalling molecules. ...

    pdf9p tumor12 20-04-2013 30 2   Download

  • We have determined the cDNA nucleotide sequence, deduced the amino acid sequence and defined the gene structure for the cellular heart-type (H-FABP) or fatty acid-binding protein 3 (FABP3) from zebrafish. The zebrafish FABP3 exhibited the greatest amino acid sequence identity to fish andmammalian heart-type FABPs. 3¢RACE and 5¢ RLM-RACE mapped two alternative polyadenylation sites and three transcription start sites, respectively.

    pdf12p tumor12 20-04-2013 34 2   Download

  • Bloodcoagulation is triggeredby the formationof acomplex between factor VIIa (FVIIa) and its cofactor, tissue factor (TF). TF–FVIIa is inhibited by tissue factor pathway inhibitor (TFPI) in two steps: first TFPI is bound to the active site of factor Xa (FXa), and subsequently FXa–TFPI exerts feedback inhibition of TF–FVIIa. The FXa-depend-ent inhibition of TF–FVIIa activity by TFPI leads to for-mation of the quaternary complex TF–FVIIa–FXa–TFPI. We used site-directed fluorescence probing to map part of the region of soluble TF (sTF) that interacts with FXa in sTF–FVIIa–FXa–TFPI. ...

    pdf7p fptmusic 16-04-2013 40 3   Download

  • Plasminogen activator inhibitor-1 (PAI-1) belongs to the serpin family of serine proteinase inhibitors. Serpins inhibit their target proteinases by an ester bond being formed between the active site serine of the proteinase and the P1 residue of the reactive centre loop (RCL) of the serpin, fol-lowed by insertion of the RCL intob-sheet A of the serpin. Concomitantly, there are conformational changes in the flexible joint region lateral tob-sheet A.

    pdf8p fptmusic 16-04-2013 28 2   Download

  • The Goodpasture antigen-binding protein, GPBP, is a serine⁄threonine kinase whose relative expression increases in autoimmune processes. Tumor necrosis factor (TNF) is a pro-inflammatory cytokine implicated in auto-immune pathogenesis. Here we show that COL4A3BP, the gene encoding GPBP, maps head-to-head withPOLK, the gene encoding for DNA polymerase kappa (polj), and shares with it a 140-bp promoter containing a Sp1 site, a TATA-like element, and a nuclear factor kappa B (NFjB)-like site

    pdf15p fptmusic 12-04-2013 36 3   Download

  • We used two inhibitors of the signaling enzyme phosphatidylinositol 3-kin-ase (PtdIns3K), wortmannin and LY294002, to evaluate the potential involvement of PtdIns3K in the activation of the MAP kinases (MAPK), Erk1 and Erk2. In dose–response studies carried out on six different cell lines and a primary cell culture, we analyzed the ability of the inhibitors to block phosphorylation of protein kinase B⁄akt (PKB⁄akt) at Ser473 as a measure of PtdIns3K activity, or the phosphorylation of Erk1⁄2 at activa-ting Thr⁄Tyr sites as a measure of the extent of activation of MAPK⁄Erk kinase (MEK⁄Erk).

    pdf13p fptmusic 11-04-2013 47 2   Download

  • We have identifiedDNA sequences required for the expres-sion of thepresenilin 1(PS1) gene. A promoter region has been mapped in SK-N-SH cells and includes sequences be-tween)118and+178flankingthemajor initiationsite (+1). ThePS1gene is also efficiently transcribed in the SH-SY5Y subclone of SK-N-SH cells. However the promoter appears tobeutilized inalternativeways inbothcell types. Sequences both upstream as well as downstream from the initiation site mapped in SK-N-SH cells were shown by 5¢-and3¢-deletion analysis to play a crucial role in both cell lines....

    pdf10p awards 05-04-2013 24 3   Download

  • he 8.5 kDa chloroplast protein CP12 is essential for assembly of the phosphoribulokinase⁄glyceraldehyde-3-phosphate dehydrogenase (GAPDH) complex fromChlamydomonas reinhardtii. After reduction of this complex with thioredoxin, phosphoribulokinase is released but CP12 remains tightly associated with GAPDH and downregulates its NADPH-dependent activity.

    pdf12p inspiron33 25-03-2013 38 4   Download

  • Levels of deoxyribonuclease I (DNase I) activityin vivo have been shown to be altered by physiological and⁄or pathological processes. However, no information is available on the regulation of DNase I gene (DNASE1) expressionin vivo orin vitro. We first mapped the transcription start sites ofDNASE1in human pancreas and in the DNase I-producing human pan-creatic cancer cell line QGP-1, and revealed a novel site12 kb upstream of exon 1, which was previously believed to be the single transcription-starting exon. ...

    pdf12p inspiron33 25-03-2013 37 3   Download

  • Eph receptor tyrosine kinases regulate many important biological pro-cesses. In the present study, we explored the substrate specificity of the EphA4 receptor tyrosine kinase using peptide arrays. We define a consen-sus substrate motif for EphA4 and go on to identify and test a number of potential EphA4 substrates and map their putative site(s) of phosphoryla-tion.

    pdf11p media19 06-03-2013 48 4   Download

  • Human glutamate carboxypeptidase II [GCPII (EC 3.4.17.21)] is recog-nized as a promising pharmacological target for the treatment and imaging of various pathologies, including neurological disorders and prostate can-cer. Recently reported crystal structures of GCPII provide structural insight into the organization of the substrate binding cavity and highlight residues implicated in substrate⁄inhibitor binding in the S1¢ site of the enzyme.

    pdf11p media19 04-03-2013 42 4   Download

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