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Splice forms
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TREM2 is a transmembrane receptor expressed by myeloid cells and acts to regulate their immune response. TREM2 governs the response of microglia to amyloid and tau pathologies in the Alzheimer’s disease (AD) brain. TREM2 is also present in a soluble form (sTREM2), and its CSF levels fuctuate as a function of AD progression.
16p
vicwell
29-02-2024
2
1
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The cytokine Osteopontin is a mediator of tumor progression and cancer metastasis. In 2006, we reported that (in addition to the full-length form -a) splice variants of Osteopontin (forms -b and -c) are produced selectively by transformed cells. Through June 2021, 36 PubMed-indexed journal articles have studied Osteopontin splice variants in various cancer patients.
14p
visharma
20-10-2023
2
2
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DNA methylation is an important biological form of epigenetic modification, playing key roles in plant development and environmental responses. These findings may provide valuable new insight into our understanding of the interaction between gene expression and methylation of drought responses in Populus.
11p
vinarcissa
21-03-2023
4
1
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The long introns of mammals are pools of evolutionary potential due to the multiplicity of sequences that permit the acquisition of novel exons. However, the permissibility of genes to this type of acquisition and its influence on the evolution of cell regulation is poorly understood.
13p
vigalileogalilei
27-02-2022
10
1
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Seed germination involves progression from complete metabolic dormancy to a highly active, growing seedling. Many factors regulate germination and these interact extensively, forming a complex network of inputs that control the seed-to-seedling transition.
18p
vialfrednobel
29-01-2022
9
0
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While intron retention (IR) is now widely accepted as an important mechanism of mammalian gene expression control, it remains the least studied form of alternative splicing. To delineate conserved features of IR, we performed an exhaustive phylogenetic analysis in a highly purified and functionally defined cell type comprising neutrophilic granulocytes from five vertebrate species spanning 430 million years of evolution.
15p
vialfrednobel
29-01-2022
2
0
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Many circular RNAs (circRNAs) are produced from back-splicing of exons of precursor mRNAs and are generally co-expressed with cognate linear RNAs. Methods for circRNA-specific knockout are lacking, largely due to sequence overlaps between forms. Here, we use base editors (BEs) for circRNA depletion.
22p
viarchimedes
26-01-2022
13
0
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While RNA is often created from linear splicing during transcription, recent studies have found that non-canonical splicing sometimes occurs. Non-canonical splicing joins 3’ and 5’ and forms the so-called circular RNA. It is now believed that circular RNA plays important biological roles such as affecting susceptibility of some diseases.
9p
vitzuyu2711
29-09-2021
10
1
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Members of the transient receptor potential (TRP) superfamily are proteins that are critical for insects to detect changes in environmental stimuli and also play key roles in their sensory physiology. Moreover, this family provides potential targets for the design of insecticides.
13p
vitzuyu2711
29-09-2021
19
1
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Alternative splicing (AS) is a regulatory mechanism used to create many forms of mature messengers RNAs (mRNAs) from the same gene. Sequencing of RNA (RNA-Seq) is an advanced technology, which has been utilized by different studies to find AS mechanisms in head and neck cancer (HNC).
9p
visilicon2711
20-08-2021
9
1
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Alternative splicing (AS) offers a main mechanism to form protein polymorphism. A growing body of evidence indicates the correlation between splicing disorders and carcinoma. Nevertheless, an overall analysis of AS signatures in stomach adenocarcinoma (STAD) is absent and urgently needed.
15p
vijeeni2711
30-06-2021
4
1
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Tomato is widely consumed vegetable in the world. It is used as raw and processed form. Tomato flowers are self as well as controlled pollinated. The crop has more than thirteen species including cultivated and wild types with huge diversity and is susceptible to diverse stress conditions. Recent advances in the biotic and abiotic stress in tomato transcriptomics have been reviewed here. Transcriptome is a particular set of RNA expressed during a stress, developmental stages or a condition in a group of cells.
31p
caygaocaolon4
04-04-2020
11
1
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Hepatopoietin (HPO) is a novel human hepatotrophic growth factor. Recently, we demonstrated that the extra-cellular ligand form of HPO can stimulate proliferation of hepatic cells via its specific receptor, which is on the surface of these cells.Also, the intracellular formofHPOpotentiates the transcriptional factor AP-1. Intriguingly, a variety of HPO complexes with different molecular masses were detected in hepatocytes.
6p
research12
23-04-2013
23
3
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The voltage gated sodiumchannel comprises apore-forming asubunit and regulatory bsubunits. We report here the identificationandcharacterizationof anovel splicingvariant of the humanb1 subunit, termed b1B. The 807 bp open reading frame of the human b1Bsubunit encodes a 268 residue protein with a calculated molecular mass of 30.4 kDa. The novel humanb1B subunit shares an identical N-terminal half (residues 1–149) with the humanb1subunit, but contains a novel C-terminal half (residues 150–268) of less than 17%sequence identity with the humanb1 subunit....
9p
fptmusic
12-04-2013
62
1
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In mouse, at least two catalytically active splice variants (mSMOaand mSMOl) of the flavin-containing spermine oxidase enzyme are present. We have demonstrated previously that the cytosolic mSMOais the major iso-form, while the mSMOlenzyme is present in both nuclear and cytoplasmic compartments and has an extra protein domain corresponding to the addi-tional exon VIa.
8p
awards
06-04-2013
31
2
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A homologue of interleukin 18 has been identified from rainbow trout,Oncorhynchus mykiss. The trout IL-18gene spans 3.7 kb and consists of six exons and five introns, sharing the same gene organization with its human coun-terpart. The putative translated protein is 199 amino acids in length with no predicted signal peptide. Analysis of the multiple sequence alignment reveals a conserved ICE cut site, resulting in a mature peptide of 162 amino acids. The trout IL-18 shares 41–45% similarity with known IL-18 molecules and contains an IL-1 family signature motif....
11p
dell39
03-04-2013
51
2
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Spermine oxidase (SMO) is a flavoenzyme involved in polyamine homeostasis in animal cells. Themouse spermine oxidasegene (mSMO) codes for splicevariants, including the previously reportedmajor active isoform, herein named alfa (a). In the present work, eight additional gene splicing variants were characterized. The heterologous expression and biochemical characterization ofthree recombinant iso-forms (namely mSMOl,-cand -d) revealed that only the recombinant protein mSMOldisplays biochemical charac-...
11p
dell39
03-04-2013
36
3
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In the salvage pathway of GDP-L-fucose, free cytosolic fucose is phosphorylated by L-fucokinase to form L-fu-cose-1-phosphate, which is then further converted to GDP-L-fucose in the reaction catalyzed by GDP-L-fucose pyrophosphorylase. We report here the cloning and expression of murine L-fucokinase and GDP-L-fucose pyrophosphorylase. MurineL-fucokinase is expressed as two transcripts of 3057 and 3270 base pairs, encoding proteins of 1019 and 1090 amino acids with predicted molecular masses of 111 kDa and 120 kDa respectively.
9p
dell39
03-04-2013
31
2
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Acetylcholinesterase subunits of type T (AChET) possess an alternatively spliced C-terminal peptide (t peptide) which endows them with amphiphilic properties, the capacity to form various homo-oligomers and to associate, as a tetra-mer, with anchoring proteins containing a proline rich attachment domain (PRAD). The t peptide contains seven conserved aromatic residues.
15p
dell39
03-04-2013
37
2
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The human kallikrein (KLK) family consists of 15 genes located on human chromosome 19q13.4. KLK11⁄hippostasin is a member of the kallikrein family and is expressed in various tissues. Two types of KLK11 isoforms, isoform 1 and isoform 2, have been predicted from cDNA sequences. Iso-form 1 has been isolated from human hippocampus, whereas isoform 2 has been isolated from prostate.
9p
inspiron33
25-03-2013
40
3
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