Stem cell biology

Glioma stem cells (GSCs) are a subpopulation of stem-like cells that contribute to glioblastoma (GBM) aggressiveness, recurrence, and resistance to radiation and chemotherapy. Therapeutically targeting the GSC population may improve patient survival, but unique vulnerabilities need to be identified.

25p vimichaelfaraday 25-03-2022 23 1   Download

Human pluripotent stem cells (hPSCs) provide powerful models for studying cellular differentiations and unlimited sources of cells for regenerative medicine. However, a comprehensive single-cell level differentiation roadmap for hPSCs has not been achieved.

19p vimichaelfaraday 25-03-2022 14 1   Download

A new study reveals comprehensive and unique epigenetic properties of glioma stem cells, leading to novel molecular insights and therapeutic potentials toward glioblastoma multiforme treatment.

3p vimichaelfaraday 25-03-2022 11 1   Download

The osteogenic differentiation markers BMP2, BMP4, COL1A1, OPN, OCN and PF4 evaluated using RT-PCR. The tumor dimensions in the hMSCs group were significantly higher than those of the remaining groups (p < 0.01). The number of metastatic foci in the BMP2+hMSCs group was significantly lower than those of the other groups (p < 0.01). The current results showed that the intraperitoneal route could be efficiently used for targeting hMSCs to the tumoral tissues for effective BMP2 delivery.

13p thiencuuchu 27-11-2021 15 1   Download

Understanding of the functions of microRNAs in breast cancer and breast cancer stem cells have been a hope for the development of new molecular targeted therapies. Here, it is aimed to investigate the differences in the expression levels of let-7a, miR10b, miR-21, miR-125b, miR-145, miR-155, miR-200c, miR-221, miR-222 and miR-335, which associated with gene and proteins in MCF-7 (parental) and MCF-7s (Mammosphere/stem cell-enriched population/CD44+/CD24-cells) cells treated with paclitaxel. MCF7s were obtained from parental MCF-7 cells.

12p thiencuuchu 27-11-2021 15 2   Download

Spermatogonial stem cells (SSCs) are pluripotent and have properties similar to embryonic stem cells. In this experiment, we collected SSCs from young mouse testis and injected it into mature female mice which were irradiated with gamma rays to bring them to a near death state.

9p tamynhan8 04-11-2020 9 1   Download

Equilibrium studies on the acid included denaturation of stem bromelain (EC 3.4.22.32) were performed by CD spectroscopy, ¯uorescence emission spectroscopy and binding of the hydrophobic dye, 1-anilino 8-naphthalene sulfonic acid (ANS). At pH 2.0, stembromelain lacks awell de®ned tertiary structure as seen by ¯uorescence and near-UVCDspectra.Far-UVCDspectra showretentionof some native like secondary structure at pH 2.0. Interdisciplinary Biotechnology Unit, Aligarh Muslim University, India Equilibrium studies on the acid included denaturation of stem bromelain (EC 3.4.22.

6p research12 29-04-2013 32 3   Download

Eukaryotic chromosomal DNA is densely packaged in the nucleus and organized into discrete domains of active and inactive chromatin. Gene loci that are activated during the process of cell differentiation undergo changes that result in modifications of specific histone tail residues and in loosening of chromatin structure. Theb-globin genes are expressed exclusively in eryth-roid cells.

10p dell39 27-03-2013 48 6   Download

Activating enhancer-binding protein (AP)-2ewas previously described as a new regulator of integrina10 expression in cartilage. In this study, we ana-lyzed the expression of AP-2ein differentiated chondrocytes and in human mesenchymal stem cells (HMSCs), which have been differentiated into chondrocytes in vitro.

11p viettel02 22-02-2013 27 3   Download

The aim of this study is to discover and characterize novel energy homeo-stasis-related molecules. We screened stock mouse embryonic stem cells established using the exchangeable gene trap method, and examined the effects of deficiency of the target gene on diet and genetic-induced obesity.

10p mobifone23 18-01-2013 27 3   Download

Epigenetic mechanisms, such as histone modifications, control eukaryotic development beyond DNA-stored information. Intrigu-ingly, there is an under-representation of repressive marks in quies-cent (resting) cells, stem cells and regenerating cells, but a selective accumulation of aberrant histone lysine methylation profiles in aging, ‘‘stressed’’ and tumor cells, particularly for the H3K9, H3K27 and H4K20 methyl marks.

65p cosis54 05-01-2013 51 4   Download

Mobilization of hematopoietic stem and progenitor cells (HSPCs) from the bone marrow to the peripheral blood is utilized in clinical HSPC transplan-tation protocols. Retention of HSPCs in the bone marrow is determined by relationships between the chemokine chemokine (C-X-C motif) ligand 12 (CXCL12) and its major receptor

16p cosis54 09-12-2012 38 3   Download

Anyone who cares about the moral and social implications of genomics, genetic engineering and biotechnology should read Michael J. Sandel’s article, ‘The Case Against Perfection’, in the April 2004 issue of The Atlantic Monthly. Sandel, the Anne T. and Robert M. Bass Professor of Government at Harvard University (where he teaches moral philosophy), is one of the deepest thinkers of this generation. He is a member of The President’s Council on Bioethics, which George W. Bush established to make recommendations concerning stem-cell research, among other issues. In this essay, with...

0p thulanh21 15-11-2011 53 1   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation...

10p thulanh13 15-10-2011 43 3   Download

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Acoel and platyhelminth models for stem-cell research...

4p toshiba4 07-09-2011 48 6   Download

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Q&A: What can microfluidics do for stem-cell research?

3p toshiba4 07-09-2011 40 5   Download

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: stem cells, influenza, pit bulls, Darwin, and more...

2p toshiba4 07-09-2011 53 6   Download

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: The ‘stem cell’ concept: is it holding us back?

6p toshiba4 07-09-2011 44 5   Download

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Compound developmental eye disorders following inactivation of TGF signaling in neural-crest stem cells...

16p toshiba3 07-09-2011 43 5   Download

Những người bị bệnh ung thư bạch cầu có nhiều lựa chọn trị liệu . Những chọn lựa là chờ đợi một cách cảnh giác, hóa trị (chemotherapy), liệu pháp sinh học / sinh học trị liệu (biological therapy), xạ trị (radiation therapy), và cấy tế bào gốc (stem cell transplant) . Nếu lá lách của bạn bị lớn lên, bác sĩ có thể đề nghị phẫu thuật loại bỏ nó . Đôi khi một sự kết hợp giữa các phương pháp trị liệu được sử dụng. ...

25p tuoanh04 12-07-2011 103 6   Download