The observer pattern
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We investigated the features of the genomic rearrangements in a cohort of 50 male individuals with proteolipid protein 1 (PLP1) copy number gain events who were ascertained with Pelizaeus-Merzbacher disease (PMD; MIM: 312080). We then compared our new data to previous structural variant mutagenesis studies involving the Xq22 region of the human genome.
17p vibransone 28-03-2024 2 2 Download
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Recent studies have suggested that individual variants do not sufficiently explain the variable expressivity of phenotypes observed in complex disorders. For example, the 16p12.1 deletion is associated with developmental delay and neuropsychiatric features in affected individuals, but is inherited in > 90% of cases from a mildly-affected parent.
21p vibransone 28-03-2024 2 2 Download
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Cancer is becoming a major public health problem globally and a leading cause of death in children in developed countries. However, little is known about the epidemiology of childhood cancer in Ethiopia. This study, therefore, assessed childhood cancer incidence patterns in Addis Ababa using the Addis Ababa city population-based cancer registry data from 2012 to 2017.
7p vileonardodavinci 23-12-2023 5 3 Download
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This study, therefore, examined both the long-term treatment patterns and overall survival (OS) in a regional Swedish cohort of female patients with metastatic breast cancer stratified by subtype in routine clinical practice during a recent eight-year period and correlation to current treatment guidelines.
12p vialfrednobel 23-12-2023 4 3 Download
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To evaluate the electrophysiological characteristics, risk stratification and ablation outcomes in patients with asymptomatic Wolf-Parkinson-White pattern at 108 Military Central Hospital. Subject and method: A retrospective observational study on 45 asymptomatic Wolf-Parkinson-White patients underwent electrophysiology study and ablation by radiofrequency energy at Department of Cardiology, 108 Military Central Hospital, from December 2018 to December 2021.
7p visoros 01-11-2023 3 1 Download
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Immunotherapy has transformed cancer treatment patterns for advanced hepatocellular carcinoma (aHCC) in recent years. Therefore, the identification of predictive biomarkers has important clinical implications.
15p visharma 20-10-2023 3 3 Download
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Effective identification and development of new molecular methods for the diagnosis, treatment and prognosis of lung adenocarcinoma (LUAD) remains an urgent clinical need. DNA methylation patterns at cytosine bases in the genome are closely related to gene expression, and abnormal DNA methylation is frequently observed in various cancers.
12p vioracle 29-09-2023 4 2 Download
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The incidence of peripherally inserted central catheter (PICC)-related complications is higher in cancer patients than in noncancer patients. However, the pattern of specific complication occurrence over time remains unclear.
11p vioracle 29-09-2023 2 2 Download
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It is an established fact that the cause of Polycystic Ovarian Disease (PCOD) has a significant hereditary component. Various researchers have also revealed that PCOD is associated with obesity and successful weight reduction is the most effective method of restoring normal ovulation and menstruation. In the present study, an attempt is made to assess the general, anthropometric, biochemical and clinical observation along with lifestyle and dietary pattern of the patients.
6p viisac 23-09-2023 5 1 Download
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Drosophila suzukii is a highly destructive pest species, causing substantial economic losses in soft fruit production. To better understand migration patterns, gene flow and adaptation in invaded regions, we studied the genetic structure of D. suzukii collected across Italy, where it was first observed in 2008.
10p vinarcissa 21-03-2023 2 1 Download
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The project's main objectives were to analyse the data obtained during geological exploration and use it to model and predict biological patterns in order to answer the main research questions: 1) Is there a statistical relationship between the environmental parameters and the benthic community composition and morphospecies observed? 2) Can predictive models be developed from this relationship? In achieving these main objectives, the project also developed recommendations for methods that could be applied during geological exploration voyages to maximise the potential use of data collected.
206p runthenight04 02-02-2023 2 1 Download
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An STR locus with tri-allelic pattern is occasionally observed in routine forensic casework. The extra copy of TPOX locus with tri-allelic pattern in populations has been assumed to be inserted into an X chromosome, which took place forth before the Bantu expansion in Africa.
9p vihagrid 30-01-2023 3 3 Download
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Ticks are a problem for cattle production mainly in tropical and subtropical regions, because they generate great economic losses. Acaricides and vaccines have been used to try to keep tick populations under control. This has been proven difficult given the resistance to acaricides and vaccines observed in ticks.
12p vihagrid 30-01-2023 5 3 Download
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Software design - Lecture 40. The main topics covered in this chapter include: observer design pattern or publish and subscribe; motivation for observer design pattern; one data multiple representations; newspaper subscription example; case for observer design pattern;...
30p haoasakura 30-05-2022 15 3 Download
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Lecture Software engineering: Lesson 26 - Fakhar Lodhi. The main topics covered in this chapter include: introduction to design patterns, design patterns, patterns format, the observer pattern, classification of design patterns, software patterns,...
26p youzhangjing_1909 28-04-2022 3 1 Download
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Lecture Software engineering: Lesson 27 - Fakhar Lodhi. The main topics covered in this chapter include: observer pattern, the singleton pattern, the facade pattern, singleton pattern example, facade pattern example, facade structure, design pattern,...
22p youzhangjing_1909 28-04-2022 8 1 Download
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In cancer, mutually exclusive or co-occurring somatic alterations across genes can suggest functional interactions. Existing tests for such patterns make the unrealistic assumption of identical gene alteration probabilities across tumors. We present Discrete Independence Statistic Controlling for Observations with Varying Event Rates (DISCOVER), a novel test that is more sensitive than other methods and controls its false positive rate.
17p vialfrednobel 29-01-2022 11 0 Download
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Transcriptome-wide m6 A patterns in Arabidopsis have been assayed recently. However, differential m6 A patterns between organs have not been well characterized. Results: Over two-third of the transcripts in Arabidopsis are modified by m6 A. In contrast to a recent observation of m6 A enrichment in 5′ mRNA, we find that m6 A is distributed predominantly near stop codons.
26p viaristotle 29-01-2022 8 1 Download
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Boops boops sexuality was studied in 664 females, 201 males, and 103 hermaphrodites collected from central Algerian coast ports between December 2013 and November 2014. Histoanatomical observations were performed to describe the sexual pattern of B. boops. Observation of the evolution of sexual maturity stages as well as the gonadosomatic report have established the breeding period of B. boops as between February and June. The B. boops population fished here is in favor of females, with a percentage of 76.76% against 23.34% for males.
18p dolomite36 30-12-2021 5 0 Download
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Gonadal sex differentiation proceeds by the interplay of various genes including the transcription factors and secretory factors in a complex network. Dmrt1 and Sox9 were considered to be the essential genes involved in the testicular differentiation in mammals, birds, reptiles, and fishes. Here, we have successfully isolated and characterized cDNAs encoding the Rana chensinensis orthologs of Dmrt1 and Sox9, and we have determined patterns of expression during gonadal differentiation and adult tissues.
12p dolomite36 30-12-2021 8 0 Download